Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 9/20 | 0.44 |
| ▸ | PPARG | P37231 | 5/20 | 0.44 |
| ▸ | RARG | P13631 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | RARB | P10826 | 2/20 | 0.40 |
| ▸ | RARA | P10276 | 3/20 | 0.39 |
| ▸ | RXRB | P28702 | 2/20 | 0.39 |
| ▸ | RXRG | P48443 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | THRA | P10827 | 4/20 | 0.36 |
| ▸ | THRB | P10828 | 4/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4850986 | 0.88 | RXRA (0.41) | RXRAPPARGRARGKMT2ARARA | |
| SCHEMBL4852964 | 0.78 | RXRA (0.46) | RXRAPPARGRARGRARBRARA | |
| SCHEMBL6692114 | 0.78 | LMNA (0.43) | RXRAPPARGRARGMEN1KMT2A | |
| SCHEMBL8780259 | 0.75 | GLRA1 (0.53) | MEN1KMT2AALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL9191371 | 0.74 | RXRA (0.60) | RXRAPPARGRARGRARBRARA | |
| SCHEMBL10212529 | 0.74 | RXRA (0.46) | RXRAPPARGRARGRARBRARA | |
| SCHEMBL14416510 | 0.74 | THRB (0.43) | MEN1KMT2ASMN1; SMN2RAB9ATHRA | |
| SCHEMBL6687586 | 0.73 | RXRA (0.53) | RXRAPPARGRARGRARBRARA | |
| Zinc Ion SCHEMBL9191366 | 0.73 | RXRA (0.56) | RXRAPPARGRARGRARBRARA | |
| SCHEMBL7067871 | 0.72 | MEN1 (0.40) | MEN1KMT2AALDH1A1SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004069781-A2 | 7-(3,5-DIISOPROPYLPHENYL) HEPTATRIENOIC ACID DERIVATIVES HAVING SERUM GLUCOSE REDUCING ACTIVITY | ALLERGAN, INC. (US) | 2004-08-19 | — | — | WO | disclosed |
| US-6759546-B1 | REDUCING SERUM GLUCOSE AND SERUM TRIGLYCERIDE LEVELS IN DIABETIC MAMMALS WITHOUT THE UNDESIRABLE PROPERTY OF REDUCING SERUM THYROXINE LEVELS | ALLERGAN, INC. | 2004-07-06 | — | — | US | disclosed |