Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.42 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.42 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.42 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.42 |
| ▸ | ESR1 | P03372 | 3/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27540906 | 0.76 | CACNA1F (0.44) | HRH3CACNA1FCACNA1DCACNA1SCACNA1C | |
| Hydrochloric Acid SCHEMBL497091 | 0.75 | HRH3 (0.67) | HRH3KCNH2 | |
| SCHEMBL28036131 | 0.71 | ALDH1A1 (0.41) | — | |
| SCHEMBL1929134 | 0.71 | LTA4H (0.52) | HRH3KCNH2DRD2DRD3SMN1; SMN2 | |
| SCHEMBL1927451 | 0.71 | ESR1 (0.56) | ESR1ESR2SMN1; SMN2 | |
| SCHEMBL1929557 | 0.70 | POLB (0.50) | HRH3KCNH2SMN1; SMN2 | |
| SCHEMBL1927551 | 0.70 | KCNH2 (0.51) | HRH3KCNH2DRD2DRD3SMN1; SMN2 | |
| SCHEMBL1928729 | 0.70 | KCNH2 (0.51) | HRH3KCNH2DRD2DRD3SMN1; SMN2 | |
| SCHEMBL1928414 | 0.69 | HRH3 (0.57) | HRH3SMN1; SMN2 | |
| SCHEMBL28470739 | 0.68 | DRD2 (0.54) | DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421074-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2004-05-26 | — | — | EP | disclosed |
| WO-2003010158-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2003-02-06 | — | — | WO | disclosed |