Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 10/20 | 0.47 |
| ▸ | CA2 | P00918 | 10/20 | 0.47 |
| ▸ | CA12 | O43570 | 6/20 | 0.47 |
| ▸ | CA9 | Q16790 | 6/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | STK17B | O94768 | 1/20 | 0.39 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1882369 | 0.94 | TDP1 (0.61) | MEN1GAAKMT2ATDP1MAOA | |
| SCHEMBL26859671 | 0.90 | MEN1 (0.54) | MEN1GAAKMT2ATDP1MAOA | |
| SCHEMBL4926959 | 0.90 | GAA (0.51) | MEN1GAAKMT2ATDP1MAOA | |
| SCHEMBL13419528 | 0.86 | MEN1 (0.60) | MEN1GAAKMT2ATDP1MAOA | |
| SCHEMBL7272725 | 0.83 | MEN1 (0.60) | MEN1GAAKMT2ATDP1MAOA | |
| SCHEMBL26859657 | 0.83 | TDP1 (0.51) | MEN1GAAKMT2ATDP1MAOA | |
| SCHEMBL7426739 | 0.82 | TDP1 (0.62) | MEN1GAAKMT2ATDP1MAOA | |
| SCHEMBL238415 | 0.82 | MEN1 (0.64) | MEN1GAAKMT2ATDP1MAOA | |
| SCHEMBL13504177 | 0.82 | EPHX1 (0.50) | MEN1GAAKMT2ATDP1EPHX1 | |
| SCHEMBL22975179 | 0.81 | TDP1 (0.50) | MEN1GAAKMT2ATDP1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3030244-B1 | POLYCONJUGATES FOR DELIVERY OF RNAI TRIGGERS TO TUMOR CELLS IN VIVO | ARROWHEAD PHARMACEUTICALS INC (US) | 2021-04-21 | — | — | EP | disclosed |
| US-20170022497-A1 | Polyconjugates for Delivery of RNAi triggers to Tumor Cells In Vivo | Arrowhead Pharmaceuticals, Inc. | 2017-01-26 | — | — | US | disclosed |
| US-9487556-B2 | Polyconjugates for delivery of RNAi triggers to tumor cells in vivo | Arrowhead Pharmaceuticals, Inc. (US) | 2016-11-08 | — | — | US | disclosed |
| US-9452221-B2 | Poly(acrylate) polymers for in vivo nucleic acid delivery | Arrowhead Pharmaceuticals, Inc. (US) | 2016-09-27 | — | — | US | disclosed |
| US-20150104408-A1 | Poly(acrylate) Polymers for In Vivo Nucleic Acid Delivery | Arrowhead Madison Inc. (US) | 2015-04-16 | — | — | US | disclosed |
| EP-2838544-A1 | POLY(ACRYLATE) POLYMERS FOR IN VIVO NUCLEIC ACID DELIVERY | Arrowhead Research Corporation (US) | 2015-02-25 | — | — | EP | disclosed |
| US-20150045573-A1 | Polyconjugates for Delivery of RNAi triggers to Tumor Cells In Vivo | Arrowhead Pharmaceuticals, Inc. | 2015-02-12 | — | — | US | disclosed |
| US-8933047-B2 | Poly(acrylate) polymers for in vivo nucleic acid delivery | Arrowhead Madison Inc. (US) | 2015-01-13 | — | — | US | disclosed |
| US-8802773-B2 | In vivo polynucleotide delivery conjugates having enzyme sensitive linkages | Arrowhead Madison Inc. (US) | 2014-08-12 | — | — | US | disclosed |
| US-20130317079-A1 | Poly(acrylate) Polymers for In Vivo Nucleic Acid Delivery | Arrowhead Madison Inc. (US) | 2013-11-28 | — | — | US | disclosed |
| WO-2013158141-A1 | POLY(ACRYLATE) POLYMERS FOR IN VIVO NUCLEIC ACID DELIVERY | ARROWHEAD RESEARCH CORPORATION (US) | 2013-10-24 | — | — | WO | disclosed |
| US-20130190484-A1 | In Vivo Polynucleotide Delivery Conjugates Having Enzyme Sensitive Linkages | Arrowhead Madison Inc. (US) | 2013-07-25 | — | — | US | disclosed |
| US-8426554-B2 | In vivo polynucleotide delivery conjugates having enzyme sensitive linkages | Arrowhead Madison Inc. (US) | 2013-04-23 | — | — | US | disclosed |
| US-20120172412-A1 | In Vivo Polynucleotide Delivery Conjugates Having Enzyme Sensitive Linkages | Arrowhead Madison Inc. (US) | 2012-07-05 | — | — | US | disclosed |
| WO-2004074335-A1 | NOVEL CATIONIC POLYMERS AND COPOLYMERS, USE THEREOF FOR THE VECTORISATION OF BIOMOLECULES AND SYNTHETIC INTERMEDIATES FOR THE SAME | HALISOL (FR) | 2004-09-02 | — | — | WO | disclosed |
| EP-0821018-A2 | Crosslinkable olefinic polymers and method for their preparation | PCD-Polymere Gesellschaft m.b.H. (AT) | 1998-01-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130317079-A1 | Poly(acrylate) Polymers for In Vivo Nucleic Acid Delivery | PHAX, PARN, PARG | MEN1 3008/4885GAA 1031/4885KMT2A 3056/4885 |
| US-20170022497-A1 | Polyconjugates for Delivery of RNAi triggers to Tumor Cells In Vivo | PAM, PLAUR, M6PR | MEN1 483/4885GAA 453/4885KMT2A 734/4885 |
| US-20150045573-A1 | Polyconjugates for Delivery of RNAi triggers to Tumor Cells In Vivo | PAM, PLAUR, M6PR | MEN1 483/4885GAA 453/4885KMT2A 734/4885 |
| US-20120172412-A1 | In Vivo Polynucleotide Delivery Conjugates Having Enzyme Sensitive Linkages | RNASE1, PNKP, POLM | MEN1 1759/4885GAA 91/4885KMT2A 949/4885 |
| US-20130190484-A1 | In Vivo Polynucleotide Delivery Conjugates Having Enzyme Sensitive Linkages | RNASE1, PNKP, POLM | MEN1 1759/4885GAA 91/4885KMT2A 949/4885 |
| US-20150104408-A1 | Poly(acrylate) Polymers for In Vivo Nucleic Acid Delivery | PHAX, PARN, PARG | MEN1 3008/4885GAA 1031/4885KMT2A 3056/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.