SCHEMBL3276799

SCHEMBL3276799

CC(C)(C)OC(=O)N[C@@H](CO)CC(=O)OCc1ccccc1

nearest known ligand 0.59

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
SYK P43405 1/20 0.59
KLK5 Q9Y337 3/20 0.53
KLK7 P49862 1/20 0.53
ATM Q13315 1/20 0.53
PPARA Q07869 3/20 0.50
CTSS P25774 4/20 0.47
CTSL P07711 2/20 0.47
MAPT P10636 1/20 0.47
CTRB1 P17538 2/20 0.46
PPARG P37231 2/20 0.46
CTSK P43235 2/20 0.46
CTSB P07858 1/20 0.46
APP P05067 1/20 0.44
ACE P12821 1/20 0.44
ALDH1A1 P00352 1/20 0.43
MAPK1 P28482 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3108565 1.00 SYK (0.59) SYKKLK5KLK7ATMPPARA
SCHEMBL1262680 1.00 SYK (0.59) SYKKLK5KLK7ATMPPARA
SCHEMBL18976490 0.90 SYK (0.57) SYKKLK5KLK7ATMPPARA
SCHEMBL31154007 0.90 SYK (0.57) SYKKLK5KLK7ATMPPARA
SCHEMBL15928906 0.90 ATM (0.62) SYKKLK5KLK7ATMPPARA
SCHEMBL17207697 0.90 SYK (0.59) SYKKLK5KLK7ATMPPARA
SCHEMBL14119009 0.90 ATM (0.62) SYKKLK5KLK7ATMPPARA
SCHEMBL6685926 0.90 SYK (0.59) SYKKLK5KLK7ATMPPARA
SCHEMBL6685929 0.90 SYK (0.59) SYKKLK5KLK7ATMPPARA
SCHEMBL5197783 0.90 SYK (0.62) SYKKLK5KLK7ATMPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 87 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250340574-A1 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR VERTEX PHARMA (US) 2025-11-06 US disclosed
US-20250320196-A1 APOL1 INHIBITORS AND METHODS OF USES THEREOF MAZE THERAPEUTICS INC (US) 2025-10-16 US disclosed
US-12378206-B2 Heteroaryl butanoic acid derivatives NOVARTIS AG (CH) 2025-08-05 US disclosed
US-20250197387-A1 BCL-XL DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2025-06-19 US disclosed
WO-2025064952-A1 BCL-2 INHIBITORS Eil Therapeutics, Inc. (US) 2025-03-27 WO disclosed
US-12240862-B2 Inhibitors of peptidylarginine deiminases GILEAD SCIENCES, INC. (US) 2025-03-04 US disclosed
EP-4504739-A1 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR Vertex Pharmaceuticals Incorporated (US) 2025-02-12 EP disclosed
EP-4401729-A1 BCL-XL DEGRADERS AND USES THEREOF Kymera Therapeutics, Inc. (US) 2024-07-24 EP disclosed
US-20240150377-A1 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR VERTEX PHARMACEUTICALS INCORPORATED 2024-05-09 US disclosed
US-11976083-B2 Inhibitors of peptidylarginine deiminases GILEAD SCIENCES, INC. (US) 2024-05-07 US disclosed
US-20170015637-A1 NOVEL HETEROARYL BUTANOIC ACID DERIVATIVES NOVARTIS AG (CH) 2017-01-19 US disclosed
US-20170015637-A1 NOVEL HETEROARYL BUTANOIC ACID DERIVATIVES NOVARTIS AG (CH) 2017-01-19 US disclosed
WO-2015092740-A1 HETEROARYL BUTANOIC ACID DERIVATIVES AS LTA4H INHIBITORS NOVARTIS AG (CH) 2015-06-25 WO disclosed
EP-1330436-B1 N-(4-ARYLOXYPIPERIDIN-1-YLALKYL) CINNAMIC AMIDES AS CCR3-3 RECEPTOR ANTAGONISTS NOVARTIS AG (CH) 2010-06-30 EP disclosed
US-20070129371-A1 Novel ethylenediamine derivatives DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2007-06-07 US disclosed
US-20070129371-A1 Novel ethylenediamine derivatives DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2007-06-07 US disclosed
US-7034042-B2 N-(4-aryloxypiperidin-1-ylalkyl) cinnamic amides as CCR33 receptor antagonists NOVARTIS AG (CH) 2006-04-25 US disclosed
US-20040087621-A1 N-(4-aryloxypiperidin-1-ylalkyl) cinnamic amides as ccr33 receptor antagonists NOVARTIS AG (CH) 2004-05-06 US disclosed
EP-1330436-A1 N-(4-ARYLOXYPIPERIDIN-1-YLALKYL) CINNAMIC AMIDES AS CCR3-3 RECEPTOR ANTAGONISTS Novartis AG (CH) 2003-07-30 EP disclosed
WO-2002030898-A1 N-(4-ARYLOXYPIPERIDIN-1-YLALKYL) CINNAMIC AMIDES AS CCR33 RECEPTOR ANTAGONISTS NOVARTIS AG (CH) 2002-04-18 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070129371-A1 Novel ethylenediamine derivatives C1R, C9, C1S SYK 2242/4885KLK5 4138/4885KLK7 4271/4885
US-12378206-B2 Heteroaryl butanoic acid derivatives LTA4H, LTC4S, LTB4R SYK 4427/4885KLK5 3013/4885KLK7 4015/4885
US-20250340574-A1 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR CFTR, SCNN1G, SCNN1B SYK 3905/4885KLK5 4100/4885KLK7 4265/4885
US-20250320196-A1 APOL1 INHIBITORS AND METHODS OF USES THEREOF APOL1, APOB, LDLR SYK 4397/4885KLK5 2496/4885KLK7 3322/4885
US-11976083-B2 Inhibitors of peptidylarginine deiminases PADI4, PADI2, PADI1 SYK 2600/4885KLK5 3823/4885KLK7 4491/4885
US-20040087621-A1 N-(4-aryloxypiperidin-1-ylalkyl) cinnamic amides as ccr33 receptor antagonists CCR1, CCR3, CCR8 SYK 4125/4885KLK5 3864/4885KLK7 4015/4885
US-20250197387-A1 BCL-XL DEGRADERS AND USES THEREOF XIAP, BCL2L1, BCL2L10 SYK 1806/4885KLK5 4429/4885KLK7 4196/4885
US-20170015637-A1 NOVEL HETEROARYL BUTANOIC ACID DERIVATIVES LTA4H, LTC4S, LTB4R SYK 4485/4885KLK5 3017/4885KLK7 4031/4885
US-12240862-B2 Inhibitors of peptidylarginine deiminases PADI4, PADI2, PADI1 SYK 2600/4885KLK5 3823/4885KLK7 4491/4885
US-20240150377-A1 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR CFTR, SCNN1G, SCNN1B SYK 4109/4885KLK5 4189/4885KLK7 4326/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.