Morpholine

Morpholine

SCHEMBL6562102

C1COCCN1.CC#N.Cc1ccc(S(=O)(=O)O)cc1

nearest known ligand 0.41

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Morpholine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.39
ALDH1A1 P00352 6/20 0.39
LMNA P02545 2/20 0.39
MAPT P10636 4/20 0.38
TDP1 Q9NUW8 3/20 0.38
KDM4E B2RXH2 1/20 0.38
HTT P42858 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
CYP3A4 P08684 3/20 0.38
CYP2C9 P11712 2/20 0.38
CYP2C19 P33261 2/20 0.38
CYP2D6 P10635 2/20 0.38
PKM P14618 1/20 0.38
USP2 O75604 1/20 0.38
NPC1 O15118 2/20 0.37
GAA P10253 1/20 0.37
TSHR P16473 1/20 0.37
NT5E P21589 1/20 0.37
PRSS1 P07477 1/20 0.37
ACR P10323 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Morpholine SCHEMBL890524 0.92 L3MBTL1 (0.43) L3MBTL1ALDH1A1LMNAMAPTTDP1
Oxazolidine SCHEMBL10370071 0.83 LMNA (0.41) L3MBTL1ALDH1A1LMNAMAPTTDP1
Acetonitrile SCHEMBL27393612 0.82 CYP2D6 (0.50) L3MBTL1ALDH1A1LMNAMAPTHTT
Aziridine SCHEMBL5185484 0.82 ALDH1A1 (0.50) L3MBTL1ALDH1A1LMNAMAPTTDP1
Acetonitrile SCHEMBL17474635 0.82 ALDH1A1 (0.52) L3MBTL1ALDH1A1LMNAMAPTTDP1
Acetonitrile SCHEMBL318491 0.82 ALDH1A1 (0.52) L3MBTL1ALDH1A1LMNAMAPTTDP1
Acetonitrile SCHEMBL29256909 0.82 ALDH1A1 (0.52) L3MBTL1ALDH1A1LMNAMAPTTDP1
Dioxane SCHEMBL11309706 0.81 L3MBTL1 (0.49) L3MBTL1ALDH1A1LMNAMAPTTDP1
Acetonitrile SCHEMBL28546118 0.81 ALDH1A1 (0.50) L3MBTL1ALDH1A1LMNAMAPTTDP1
Acetonitrile SCHEMBL9780143 0.81 ALDH1A1 (0.50) L3MBTL1ALDH1A1LMNAMAPTTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6764613-B2 FOR USE IN BLEACHING AND CLEANING MID-AMERICA COMMERCIALIZATION CORPORATION 2004-07-20 US disclosed
EP-1036070-B1 N-ALKYL AMMONIUM ACETONITRILE SALTS, METHODS THEREFOR AND COMPOSITIONS THEREWITH CLOROX CO (US) 2004-02-18 EP disclosed
US-20030080319-A1 N-alkyl ammonium acetonitrile salts, methods therefor and compositions therewith THE CLOROX COMPANY 2003-05-01 US disclosed
EP-0944609-B1 PROCESS FOR PREPARING N-ALKYL AMMONIUM ACETONITRILE COMPOUNDS CLOROX CO (US) 2003-04-02 EP disclosed
EP-0951438-A4 GRANULAR N-ALKYL AMMONIUM ACETONITRILE COMPOSITIONS CLOROX CO (US) 2002-08-14 EP disclosed
EP-0948455-A4 MIXED PEROXYGEN ACTIVATOR COMPOSITIONS CLOROX CO (US) 2002-03-13 EP disclosed
US-6235218-B1 REACTING HETEROCYCLIC AMINE WITH MONOALDEHYDE OR DIALDEHYDE AND HYDROGEN CYANIDE OR ALKALI METAL CYANIDE IN AQUEOUS MEDIUM, QUATERNIZING AMINE WITH ALKYLATING AGENT AT PH CONTROLLED TO PREVENT FORMATION OF PROTONATED INTERMEDIATE THE CLOROX COMPANY 2001-05-22 US disclosed
US-6183665-B1 BLEACHING THE CLOROX COMPANY 2001-02-06 US disclosed
EP-0951438-A1 GRANULAR N-ALKYL AMMONIUM ACETONITRILE COMPOSITIONS BASF AKTIENGESELLSCHAFT (DE) 1999-10-27 EP disclosed
EP-0948455-A1 MIXED PEROXYGEN ACTIVATOR COMPOSITIONS The Clorox Company (US) 1999-10-13 EP disclosed
US-5888419-A BLEACHING, LAUNDERING COMPOUNDS THE CLOROX COMPANY (US) 1999-03-30 US disclosed
US-5814242-A HETEROCYCLIC CATIONIC SPECIES THE CLOROX COMPANY (US) 1998-09-29 US disclosed
WO-1998023534-A1 MIXED PEROXYGEN ACTIVATOR COMPOSITIONS THE CLOROX COMPANY (US) 1998-06-04 WO disclosed
WO-1998023531-A1 GRANULAR N-ALKYL AMMONIUM ACETONITRILE COMPOSITIONS THE CLOROX COMPANY (US) 1998-06-04 WO disclosed