SCHEMBL668622

SCHEMBL668622

CC(=O)Nc1ccc(OC(=O)CCl)cc1

nearest known ligand 0.68

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 7/20 0.68
MEN1 O00255 4/20 0.68
OPRK1 P41145 1/20 0.63
NPSR1 Q6W5P4 1/20 0.58
SMN1; SMN2 Q16637 3/20 0.58
HSD17B10 Q99714 2/20 0.58
ALDH1A1 P00352 3/20 0.57
TDP1 Q9NUW8 2/20 0.57
TP53 P04637 1/20 0.57
HIF1A Q16665 1/20 0.57
LMNA P02545 1/20 0.57
CYP1A2 P05177 1/20 0.57
MAPT P10636 2/20 0.54
ESR2 Q92731 1/20 0.53
HTT P42858 1/20 0.53
HPGD P15428 1/20 0.51
CA1 P00915 1/20 0.50
CA2 P00918 1/20 0.50
CA9 Q16790 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29157013 0.89 KMT2A (0.62) KMT2AMEN1OPRK1NPSR1SMN1; SMN2
SCHEMBL12291744 0.87 KMT2A (0.75) KMT2AMEN1OPRK1NPSR1SMN1; SMN2
SCHEMBL1930736 0.84 KMT2A (0.70) KMT2AMEN1OPRK1NPSR1SMN1; SMN2
SCHEMBL9823523 0.84 KMT2A (0.70) KMT2AMEN1OPRK1NPSR1SMN1; SMN2
SCHEMBL12291743 0.83 KMT2A (0.68) KMT2AMEN1OPRK1NPSR1SMN1; SMN2
SCHEMBL3805817 0.83 KMT2A (0.68) KMT2AMEN1OPRK1NPSR1SMN1; SMN2
SCHEMBL12987121 0.83 KMT2A (0.68) KMT2AMEN1OPRK1NPSR1SMN1; SMN2
SCHEMBL13195809 0.81 KMT2A (0.71) KMT2AMEN1OPRK1NPSR1SMN1; SMN2
SCHEMBL14808444 0.81 KMT2A (1.00) KMT2AMEN1OPRK1NPSR1SMN1; SMN2
SCHEMBL4095285 0.81 KMT2A (0.52) KMT2AMEN1SMN1; SMN2HSD17B10ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114907226-B Industrial preparation method of propacetamol hydrochloride 安徽威尔曼制药有限公司 2024-05-14 CN disclosed
CN-115501192-B Preparation method of propacetamol hydrochloride for injection 海南皇隆制药股份有限公司 2024-02-23 CN disclosed
CN-115501192-A Preparation method of propacetamol hydrochloride for injection 海南皇隆制药股份有限公司 2022-12-23 CN disclosed
CN-114907226-A Industrial preparation method of propacetamol hydrochloride 安徽威尔曼制药有限公司 2022-08-16 CN disclosed
CN-114907226-A Industrial preparation method of propacetamol hydrochloride 安徽威尔曼制药有限公司 2022-08-16 CN disclosed
US-9278134-B2 Dual functioning ionic liquids and salts thereof THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA (US) 2016-03-08 US disclosed
US-9278134-B2 Dual functioning ionic liquids and salts thereof THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA (US) 2016-03-08 US disclosed
US-9278134-B2 Dual functioning ionic liquids and salts thereof THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA (US) 2016-03-08 US disclosed
CN-104030938-A Method for preparing propacetamol hydrochloride ANHUI YOUCARE KAIYUE PHARMACEUTICAL CO LTD 2014-09-10 CN disclosed
US-20120046244-A1 DUAL FUNCTIONING IONIC LIQUIDS AND SALTS THEREOF THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA (US) 2012-02-23 US disclosed
US-20120046244-A1 DUAL FUNCTIONING IONIC LIQUIDS AND SALTS THEREOF THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA (US) 2012-02-23 US disclosed
US-20120046244-A1 DUAL FUNCTIONING IONIC LIQUIDS AND SALTS THEREOF THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA (US) 2012-02-23 US disclosed
WO-2010078300-A1 DUAL FUNCTIONING IONIC LIQUIDS AND SALTS THEREOF THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA (US) 2010-07-08 WO disclosed
WO-2010078300-A1 DUAL FUNCTIONING IONIC LIQUIDS AND SALTS THEREOF THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA (US) 2010-07-08 WO disclosed
CN-101353314-A Preparation of propacetamol hydrochloride ANHUI SIFO PHARMACEUTICAL CO L (CN) 2009-01-28 CN disclosed
US-4127671-A ANALGESIC SOCIETE ANONYME DITE: HEXACHIME (FR) 1978-11-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120046244-A1 DUAL FUNCTIONING IONIC LIQUIDS AND SALTS THEREOF SLC6A6, SLC10A2, CLK2 KMT2A 4341/4885MEN1 2209/4885OPRK1 1568/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.