SCHEMBL4095285

SCHEMBL4095285

O=C(CCl)Oc1ccc(OC(=O)CCl)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 7/20 0.52
LMNA P02545 3/20 0.52
ALDH1A1 P00352 2/20 0.52
MAPT P10636 2/20 0.52
HTT P42858 1/20 0.52
HSD17B10 Q99714 1/20 0.52
ESR1 P03372 2/20 0.47
HIF1A Q16665 2/20 0.47
RECQL P46063 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
ELANE P08246 1/20 0.42
MEN1 O00255 1/20 0.41
GAA P10253 1/20 0.41
RAB9A P51151 2/20 0.41
BCL9 O00512 1/20 0.40
CTNNB1 P35222 1/20 0.40
CASP3 P42574 1/20 0.39
SENP8 Q96LD8 1/20 0.39
SENP7 Q9BQF6 1/20 0.39
SENP6 Q9GZR1 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10768902 0.91 KMT2A (0.49) KMT2ALMNAALDH1A1MAPTHTT
SCHEMBL9792720 0.91 KMT2A (0.45) KMT2ALMNAALDH1A1MAPTHTT
SCHEMBL11556226 0.89 KMT2A (0.44) KMT2ALMNAALDH1A1MAPTHTT
SCHEMBL4645765 0.89 GAA (0.56) KMT2ALMNAALDH1A1MAPTHTT
SCHEMBL10500407 0.89 LMNA (0.57) KMT2ALMNAALDH1A1MAPTHTT
SCHEMBL4643998 0.89 MGLL (0.46) KMT2ALMNAALDH1A1MAPTHTT
SCHEMBL10499664 0.89 KMT2A (0.44) KMT2ALMNAALDH1A1MAPTHTT
SCHEMBL137047 0.88 CYP19A1 (0.52) KMT2ALMNAALDH1A1MAPTHTT
SCHEMBL6458347 0.87 GSK3B (0.55) KMT2ALMNAALDH1A1MAPTHTT
SCHEMBL11147697 0.87 NPSR1 (0.47) KMT2ALMNAALDH1A1MAPTHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8802147-B2 Controlled release of biologically active compounds BEZWADA BIOMEDICAL, LLC (US) 2014-08-12 US disclosed
US-8802147-B2 Controlled release of biologically active compounds BEZWADA BIOMEDICAL, LLC (US) 2014-08-12 US disclosed
US-8802147-B2 Controlled release of biologically active compounds BEZWADA BIOMEDICAL, LLC (US) 2014-08-12 US disclosed
US-20140099370-A1 CONTROLLED RELEASE OF BIOLOGICALLY ACTIVE COMPOUNDS BEZWADA BIOMEDICAL, LLC (US) 2014-04-10 US disclosed
US-8552139-B2 Controlled release of biologically active compounds BEZWADA BIOMEDICAL LLC (US) 2013-10-08 US disclosed
US-8552139-B2 Controlled release of biologically active compounds BEZWADA BIOMEDICAL LLC (US) 2013-10-08 US disclosed
US-8552139-B2 Controlled release of biologically active compounds BEZWADA BIOMEDICAL LLC (US) 2013-10-08 US disclosed
US-20130142752-A1 CONTROLLED RELEASE OF BIOLOGICALLY ACTIVE COMPOUNDS BEZWADA BIOMEDICAL, LLC (US) 2013-06-06 US disclosed
US-20130142752-A1 CONTROLLED RELEASE OF BIOLOGICALLY ACTIVE COMPOUNDS BEZWADA BIOMEDICAL, LLC (US) 2013-06-06 US disclosed
US-20130142752-A1 CONTROLLED RELEASE OF BIOLOGICALLY ACTIVE COMPOUNDS BEZWADA BIOMEDICAL, LLC (US) 2013-06-06 US disclosed
US-8217134-B2 Controlled release of biologically active compounds BEZWADA BIOMEDICAL, LLC (US) 2012-07-10 US disclosed
US-8217134-B2 Controlled release of biologically active compounds BEZWADA BIOMEDICAL, LLC (US) 2012-07-10 US disclosed
US-8217134-B2 Controlled release of biologically active compounds BEZWADA BIOMEDICAL, LLC (US) 2012-07-10 US disclosed
US-20090060979-A1 CONTROLLED RELEASE OF BIOLOGICALLY ACTIVE COMPOUNDS BEZWADA BIOMEDICAL, LLC 2009-03-05 US disclosed
US-20090060979-A1 CONTROLLED RELEASE OF BIOLOGICALLY ACTIVE COMPOUNDS BEZWADA BIOMEDICAL, LLC 2009-03-05 US disclosed
US-20090060979-A1 CONTROLLED RELEASE OF BIOLOGICALLY ACTIVE COMPOUNDS BEZWADA BIOMEDICAL, LLC 2009-03-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130142752-A1 CONTROLLED RELEASE OF BIOLOGICALLY ACTIVE COMPOUNDS GUSB, BMP2, APEH KMT2A 4078/4885LMNA 2670/4885ALDH1A1 1816/4885
US-20090060979-A1 CONTROLLED RELEASE OF BIOLOGICALLY ACTIVE COMPOUNDS GUSB, BMP2, APEH KMT2A 4078/4885LMNA 2670/4885ALDH1A1 1816/4885
US-20140099370-A1 CONTROLLED RELEASE OF BIOLOGICALLY ACTIVE COMPOUNDS GUSB, BMP2, APEH KMT2A 4078/4885LMNA 2670/4885ALDH1A1 1816/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.