Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | PFKFB4 | Q16877 | 1/20 | 0.34 |
| ▸ | SCN8A | Q9UQD0 | 5/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.33 |
| ▸ | SCN1A | P35498 | 2/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.32 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | OGA | O60502 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3252155 | 0.82 | HSD11B1 (0.41) | HSD11B1PFKFB4SCN8ASCN9AALDH1A1 | |
| SCHEMBL3252428 | 0.78 | HSD11B1 (0.38) | HSD11B1PFKFB4SCN8ASCN9APSEN1 | |
| SCHEMBL3255295 | 0.74 | HSD11B1 (0.65) | HSD11B1MEN1KMT2APOLB | |
| SCHEMBL3254141 | 0.72 | ALOX12 (0.44) | ALDH1A1CYP2C9MEN1KMT2A | |
| SCHEMBL3248288 | 0.71 | AKT1 (0.45) | ALDH1A1KDM4E | |
| SCHEMBL3248368 | 0.70 | HSD11B1 (0.41) | HSD11B1ALDH1A1TSHRSMN1; SMN2MEN1 | |
| SCHEMBL3251004 | 0.69 | HSD11B1 (0.40) | HSD11B1ALDH1A1TSHRSMN1; SMN2MEN1 | |
| SCHEMBL3254728 | 0.68 | MEP1B (0.46) | HSD11B1ALDH1A1TSHRSMN1; SMN2KDM4E | |
| SCHEMBL3258283 | 0.68 | HSD11B1 (0.43) | HSD11B1PFKFB4ALDH1A1TSHRMEN1 | |
| SCHEMBL3256136 | 0.68 | PSEN1 (0.38) | PFKFB4SCN8APSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461325-A1 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 | BIOVITRUM AB (SE) | 2004-09-29 | — | — | EP | claimed |
| WO-2003043999-A1 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 | BIOVITRUM AB (SE) | 2003-05-30 | — | — | WO | claimed |