Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.54 |
| ▸ | EGFR | P00533 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | RECQL | P46063 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9876993 | 0.89 | MAPT (0.68) | MAPTTRPA1EGFRHSD17B10VCAM1 | |
| SCHEMBL21865015 | 0.83 | EGFR (0.60) | MAPTEGFRHSD17B10KMT2AALDH1A1 | |
| SCHEMBL6684887 | 0.83 | EGFR (0.56) | MAPTEGFRHSD17B10KMT2AALDH1A1 | |
| SCHEMBL1195413 | 0.75 | HSD17B10 (0.62) | MAPTHSD17B10VCAM1KMT2AALDH1A1 | |
| SCHEMBL272063 | 0.75 | GABRA1 (0.69) | MAPTTRPA1KMT2AALDH1A1KDM4E | |
| SCHEMBL10779476 | 0.74 | TRPA1 (0.59) | MAPTTRPA1EGFRHSD17B10KMT2A | |
| SCHEMBL38663477 | 0.74 | HSD17B10 (0.60) | MAPTHSD17B10VCAM1KMT2AALDH1A1 | |
| SCHEMBL526878 | 0.74 | HSD17B10 (0.60) | MAPTHSD17B10VCAM1KMT2AALDH1A1 | |
| SCHEMBL1353698 | 0.74 | MAPT (0.64) | MAPTEGFRHSD17B10KMT2AALDH1A1 | |
| SCHEMBL3246996 | 0.73 | APP (0.56) | MAPTEGFRKMT2AALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487841-A1 | THIOPYRIMIDINE AND ISOTHIAZOLOPYRIMIDINE KINASE INHIBITORS | Abbott Laboratories (US) | 2004-12-22 | — | — | EP | disclosed |
| WO-2003080625-A1 | THIOPYRIMIDINE AND ISOTHIAZOLOPYRIMIDINE KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2003-10-02 | — | — | WO | disclosed |