Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 1/20 | 0.40 |
| ▸ | CTSC | P53634 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSPA1A | P0DMV8 | 1/20 | 0.37 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.37 |
| ▸ | HSPA9 | P38646 | 1/20 | 0.37 |
| ▸ | HSPA2 | P54652 | 1/20 | 0.37 |
| ▸ | PTPRB | P23467 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | CTSH | P09668 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6653578 | 1.00 | ADAM17 (0.40) | ADAM17CTSCALDH1A1HPGDHSPA1A | |
| SCHEMBL6653571 | 1.00 | ADAM17 (0.40) | ADAM17CTSCALDH1A1HPGDHSPA1A | |
| SCHEMBL6653574 | 1.00 | ADAM17 (0.40) | ADAM17CTSCALDH1A1HPGDHSPA1A | |
| SCHEMBL6628049 | 0.82 | CTSK (0.44) | PTPRBCTSBCTSSCTSKCTSL | |
| SCHEMBL6628052 | 0.82 | CTSK (0.44) | PTPRBCTSBCTSSCTSKCTSL | |
| SCHEMBL6628047 | 0.82 | CTSK (0.44) | PTPRBCTSBCTSSCTSKCTSL | |
| SCHEMBL6702656 | 0.82 | CTSK (0.44) | PTPRBCTSBCTSSCTSKCTSL | |
| SCHEMBL6680450 | 0.80 | ADAM17 (0.43) | ADAM17PTPRBHDAC6SMN1; SMN2L3MBTL1 | |
| SCHEMBL6468744 | 0.76 | ALDH1A1 (0.39) | CTSCALDH1A1CTSBCTSHCTSS | |
| Hydrochloric Acid SCHEMBL6465933 | 0.75 | ALDH1A1 (0.38) | CTSCALDH1A1CTSBCTSHCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397340-A2 | CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2004-03-17 | — | — | EP | disclosed |
| WO-2002098850-A2 | CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2002-12-12 | — | — | WO | disclosed |