Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.73 |
| ▸ | MAP1LC3B | Q9GZQ8 | 3/20 | 0.71 |
| ▸ | PLK4 | O00444 | 4/20 | 0.67 |
| ▸ | PLK1 | P53350 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | RET | P07949 | 1/20 | 0.62 |
| ▸ | RAF1 | P04049 | 5/20 | 0.58 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.58 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.58 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.58 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.58 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.58 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.58 |
| ▸ | EGFR | P00533 | 1/20 | 0.58 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.58 |
| ▸ | ARAF | P10398 | 1/20 | 0.58 |
| ▸ | PIM1 | P11309 | 1/20 | 0.58 |
| ▸ | BRAF | P15056 | 1/20 | 0.58 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1394846 | 0.87 | MAP1LC3B (0.71) | LRRK2MAP1LC3BPLK4PLK1MEN1 | |
| SCHEMBL1394844 | 0.87 | MAP1LC3B (0.71) | LRRK2MAP1LC3BPLK4PLK1MEN1 | |
| SCHEMBL5774039 | 0.86 | MAP1LC3B (0.88) | LRRK2MAP1LC3BPLK4PLK1MEN1 | |
| SCHEMBL3754416 | 0.86 | MAP1LC3B (0.88) | LRRK2MAP1LC3BPLK4PLK1MEN1 | |
| SCHEMBL5774043 | 0.86 | MAP1LC3B (0.88) | LRRK2MAP1LC3BPLK4PLK1MEN1 | |
| SCHEMBL1395085 | 0.84 | PLK4 (0.79) | LRRK2MAP1LC3BPLK4PLK1MEN1 | |
| SCHEMBL6689420 | 0.84 | LRRK2 (1.00) | LRRK2RETRAF1PSEN1PSEN2 | |
| SCHEMBL1395087 | 0.84 | PLK4 (0.79) | LRRK2MAP1LC3BPLK4PLK1MEN1 | |
| SCHEMBL6694978 | 0.84 | ERBB2 (0.72) | LRRK2MAP1LC3BPLK4PLK1MEN1 | |
| SCHEMBL6689356 | 0.83 | PLK4 (0.78) | LRRK2MAP1LC3BPLK4PLK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004069998-A2 | OXINDOLE DERIVATIVES AS ANTIMICROBIAL AGENTS | ARROW THERAPEUTICS LIMITED (GB) | 2004-08-19 | — | — | WO | claimed |
| WO-2004069998-A2 | OXINDOLE DERIVATIVES AS ANTIMICROBIAL AGENTS | ARROW THERAPEUTICS LIMITED (GB) | 2004-08-19 | — | — | WO | disclosed |