Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APOB | P04114 | 4/20 | 0.56 |
| ▸ | MTTP | P55157 | 4/20 | 0.56 |
| ▸ | P2RX1 | P51575 | 2/20 | 0.51 |
| ▸ | TMPRSS4 | Q9NRS4 | 2/20 | 0.51 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.45 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | GMNN | O75496 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6687830 | 0.91 | P2RX1 (0.48) | APOBMTTPP2RX1TMPRSS4P2RX4 | |
| SCHEMBL6491647 | 0.89 | L3MBTL1 (0.47) | APOBMTTPSMN1; SMN2NPC1LMNA | |
| SCHEMBL6502779 | 0.78 | HDAC7 (0.51) | SMN1; SMN2NPC1LMNATP53HTT | |
| SCHEMBL6676886 | 0.77 | APOB (0.46) | APOBMTTPP2RX1TMPRSS4TRPV1 | |
| SCHEMBL6491531 | 0.76 | CYP2C8 (0.56) | APOBMTTPSMN1; SMN2DHODHKDM4E | |
| SCHEMBL6490383 | 0.76 | PTGS1 (0.58) | APOBMTTPP2RX1TMPRSS4P2RX4 | |
| SCHEMBL5937194 | 0.76 | CYP46A1 (0.68) | APOBMTTPP2RX1TMPRSS4CYP1A2 | |
| SCHEMBL24460414 | 0.76 | P2RX1 (0.80) | P2RX1TMPRSS4P2RX4P2RX7TRPV1 | |
| SCHEMBL6500905 | 0.75 | TRPV1 (0.50) | APOBMTTPP2RX1TMPRSS4P2RX4 | |
| SCHEMBL6497909 | 0.75 | SMO (0.52) | APOBMTTPTRPV1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1472226-A1 | HETEROCYCLIC AMIDE COMPOUNDS AS APOLIPOPROTEIN B INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-11-03 | — | — | EP | disclosed |
| WO-2003045921-A1 | HETEROCYCLIC AMIDE COMPOUNDS AS APOLIPOPROTEIN B INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-06-05 | — | — | WO | disclosed |