Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 10/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CCR2 | P41597 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6689196 | 0.92 | GAA (0.47) | PLA2G2AMAPTALDH1A1SMN1; SMN2GAA | |
| SCHEMBL6691521 | 0.91 | MAPT (0.49) | MAPTPOLBALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL6694412 | 0.91 | PLA2G2A (0.56) | PLA2G2AMAPTPOLBCCR2ALDH1A1 | |
| SCHEMBL6893888 | 0.90 | PLA2G2A (0.47) | PLA2G2AMAPTPOLBCCR2ALDH1A1 | |
| SCHEMBL6893709 | 0.88 | MAPT (0.47) | PLA2G2AMAPTPOLBCCR2ALDH1A1 | |
| SCHEMBL6897038 | 0.88 | PLA2G2A (0.46) | PLA2G2AMAPTPOLBCCR2ALDH1A1 | |
| SCHEMBL6897569 | 0.88 | MAPT (0.40) | MAPTPOLBALDH1A1SMN1; SMN2GAA | |
| SCHEMBL6688534 | 0.88 | MAPT (0.45) | MAPTPOLBALDH1A1SMN1; SMN2GAA | |
| SCHEMBL6782169 | 0.88 | PLA2G2A (0.56) | PLA2G2AMAPTCCR2ALDH1A1CYP1A2 | |
| SCHEMBL6895778 | 0.87 | PLA2G2A (0.45) | PLA2G2AMAPTPOLBCCR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |