SCHEMBL6689421

SCHEMBL6689421

CCCCOc1cccc2sc(S)nc12

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.52
MCHR1 Q99705 4/20 0.51
KDM4E B2RXH2 4/20 0.49
MEN1 O00255 4/20 0.49
KMT2A Q03164 4/20 0.49
MAPT P10636 3/20 0.49
TDP1 Q9NUW8 2/20 0.49
PKM P14618 1/20 0.49
MAPK1 P28482 1/20 0.49
EPHX2 P34913 1/20 0.43
CYP1A2 P05177 2/20 0.42
CYP2C9 P11712 2/20 0.42
CYP2C19 P33261 2/20 0.42
CYP3A4 P08684 1/20 0.42
DUSP3 P51452 1/20 0.41
GAA P10253 1/20 0.39
HPGD P15428 1/20 0.39
HTT P42858 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
TLR8 Q9NR97 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6691012 0.92 ALDH1A1 (0.54) ALDH1A1MCHR1KDM4EMEN1KMT2A
SCHEMBL6661729 0.86 ALDH1A1 (0.69) ALDH1A1KDM4EMEN1KMT2AMAPT
SCHEMBL6690900 0.82 ALDH1A1 (0.50) ALDH1A1MCHR1KDM4EMEN1KMT2A
SCHEMBL6899949 0.82 ALDH1A1 (0.50) ALDH1A1MCHR1KDM4EMEN1KMT2A
SCHEMBL2209697 0.79 ALDH1A1 (0.65) ALDH1A1KDM4EMEN1KMT2AMAPT
SCHEMBL6690756 0.78 MCHR1 (0.47) ALDH1A1MCHR1KDM4EMAPTCYP1A2
SCHEMBL6694180 0.77 KMT2A (0.45) ALDH1A1MCHR1KDM4EMEN1KMT2A
SCHEMBL9719205 0.77 MEN1 (0.37) ALDH1A1KDM4EMEN1KMT2AMAPT
SCHEMBL6697966 0.75 KMT2A (0.43) ALDH1A1MCHR1KDM4EMEN1KMT2A
SCHEMBL11785097 0.75 KCNH2 (0.44) ALDH1A1MEN1KMT2ATLR8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0869016-B1 Pneumatic radial tires BRIDGESTONE CORP (JP) 2004-03-03 EP disclosed
EP-0945482-B1 Rubber composition for tire tread and pneumatic tire using same BRIDGESTONE CORP (JP) 2004-01-28 EP disclosed
EP-0890605-B1 Pneumatic tire BRIDGESTONE CORP (JP) 2003-04-23 EP disclosed
EP-0854168-B1 Rubber composition BRIDGESTONE CORP (JP) 2003-04-02 EP disclosed
EP-1277795-A2 Pneumatic tire BRIDGESTONE CORPORATION (JP) 2003-01-22 EP disclosed
US-20020010283-A1 RUBBER COMPOSITION BRIDGESTONE CORPORATION (JP) 2002-01-24 US disclosed
US-6336486-B1 Pneumatic radical tire having cap base tread BRIDGESTONE CORPORATION (JP) 2002-01-08 US disclosed
US-6242522-B1 A DIENE BASED SYNTHETIC RUBBER OR NATURAL RUBBER BLEND CONTAINING BUTADIENE-STYRENE RUBBER, ALUMINUM HYDROXIDE POWDER, SILICA POWDER, CARBON BLACK; LOW FUEL CONSUMPTION AND WEAR RESISTANCE; IMPROVED GRIPPING IN WET AND COLD SITUATIONS BRIDGESTONE CORPORATION (JP) 2001-06-05 US disclosed
US-6186204-B1 EXCELLENT STABILITY AND CONTROLLABILITY ON WET ROADS OR A COMBINATION OF STABILITY AND CONTROLLABILITY ON WET ROADS AND EXCELLENT COMFORT OF RIDE EVEN WHEN A VEHICLE IS VIBRATING THROUGHOUT THE LIFE OF THE PNEUMATIC TIRE BRIDGESTONE CORPORATION (JP) 2001-02-13 US disclosed
EP-0948029-A2 High pressure discharge lamp NGK INSULATORS, LTD. (JP) 1999-10-06 EP disclosed
EP-0890605-A2 Pneumatic tire BRIDGESTONE CORPORATION (JP) 1999-01-13 EP disclosed
EP-0869016-A2 Pneumatic radial tires Bridgestone Corporation (JP) 1998-10-07 EP disclosed
EP-0854168-A1 Rubber composition Bridgestone Corporation (JP) 1998-07-22 EP disclosed