Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 10/20 | 0.53 |
| ▸ | MMP1 | P03956 | 9/20 | 0.53 |
| ▸ | MMP2 | P08253 | 5/20 | 0.53 |
| ▸ | MMP9 | P14780 | 4/20 | 0.53 |
| ▸ | MMP3 | P08254 | 3/20 | 0.53 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.41 |
| ▸ | LIPG | Q9Y5X9 | 2/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6693372 | 0.90 | MMP1 (0.41) | MMP13MMP1MMP2MMP9MMP3 | |
| SCHEMBL6689122 | 0.89 | EGLN1 (0.47) | MMP13MMP1MMP2MMP9MMP3 | |
| SCHEMBL6689090 | 0.88 | MMP1 (0.40) | MMP13MMP1MMP2MMP9MMP3 | |
| SCHEMBL6701978 | 0.86 | MMP13 (0.56) | MMP13MMP1MMP2MMP9MMP3 | |
| SCHEMBL6693911 | 0.84 | MMP13 (0.55) | MMP13MMP1MMP2MMP9MMP3 | |
| SCHEMBL6691004 | 0.77 | MMP13 (0.46) | MMP13MMP1MMP2MMP9MMP3 | |
| SCHEMBL6691197 | 0.73 | MMP1 (0.45) | MMP13MMP1MMP2MMP9MMP3 | |
| SCHEMBL6695540 | 0.73 | EGLN1 (0.49) | MMP13MMP1MMP2MMP9MMP3 | |
| SCHEMBL6697906 | 0.72 | MMP13 (0.69) | MMP13MMP1MMP2MMP9MMP3 | |
| SCHEMBL6693872 | 0.72 | MMP1 (0.42) | MMP13MMP1MMP2MMP9MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1134215-B1 | 2-oxo-imidazolidine-4-carboxylic acid hydroxamine compounds that inhibit matrix metalloproteinases | PFIZER PROD INC (US) | 2004-10-06 | — | — | EP | claimed |