Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 12/20 | 0.46 |
| ▸ | MMP1 | P03956 | 10/20 | 0.46 |
| ▸ | MMP2 | P08253 | 5/20 | 0.46 |
| ▸ | MMP9 | P14780 | 5/20 | 0.46 |
| ▸ | MMP3 | P08254 | 2/20 | 0.46 |
| ▸ | LIPG | Q9Y5X9 | 2/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 2/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6695530 | 0.90 | MMP1 (0.40) | MMP13MMP1MMP2MMP9MMP3 | |
| SCHEMBL6690762 | 0.83 | MMP13 (0.48) | MMP13MMP1MMP2MMP9MMP3 | |
| SCHEMBL6689488 | 0.77 | MMP13 (0.53) | MMP13MMP1MMP2MMP9MMP3 | |
| SCHEMBL7867287 | 0.76 | MMP13 (0.50) | MMP13MMP1MMP2MMP9MMP3 | |
| SCHEMBL6693912 | 0.75 | MMP13 (0.50) | MMP13MMP1MMP2MMP9MMP3 | |
| SCHEMBL6694302 | 0.73 | MMP1 (0.44) | MMP13MMP1MMP2MMP9MMP3 | |
| SCHEMBL6693880 | 0.72 | MMP1 (0.57) | MMP13MMP1MMP2MMP9MMP3 | |
| SCHEMBL6693911 | 0.71 | MMP13 (0.55) | MMP13MMP1MMP2MMP9MMP3 | |
| SCHEMBL6692070 | 0.69 | MMP13 (0.51) | MMP13MMP1MMP2MMP9MMP3 | |
| Hydroxyamine SCHEMBL7689984 | 0.69 | MMP2 (0.45) | MMP13MMP1MMP2MMP9MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1134215-B1 | 2-oxo-imidazolidine-4-carboxylic acid hydroxamine compounds that inhibit matrix metalloproteinases | PFIZER PROD INC (US) | 2004-10-06 | — | — | EP | claimed |