Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 11/20 | 0.41 |
| ▸ | MMP13 | P45452 | 10/20 | 0.41 |
| ▸ | MMP9 | P14780 | 10/20 | 0.41 |
| ▸ | MMP2 | P08253 | 7/20 | 0.41 |
| ▸ | MMP3 | P08254 | 4/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 7/20 | 0.41 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.40 |
| ▸ | MMP7 | P09237 | 2/20 | 0.40 |
| ▸ | MMP8 | P22894 | 2/20 | 0.40 |
| ▸ | MMP14 | P50281 | 2/20 | 0.40 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.40 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.40 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | MMP10 | P09238 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6689488 | 0.90 | MMP13 (0.53) | MMP1MMP13MMP9MMP2MMP3 | |
| SCHEMBL6689090 | 0.89 | MMP1 (0.40) | MMP1MMP13MMP9MMP2MMP3 | |
| SCHEMBL6701978 | 0.87 | MMP13 (0.56) | MMP1MMP13MMP9MMP2MMP3 | |
| SCHEMBL6691197 | 0.83 | MMP1 (0.45) | MMP1MMP13MMP9MMP2MMP3 | |
| SCHEMBL6689122 | 0.81 | EGLN1 (0.47) | MMP1MMP13MMP9MMP2MMP3 | |
| SCHEMBL6695530 | 0.77 | MMP1 (0.40) | MMP1MMP13MMP9MMP2MMP3 | |
| SCHEMBL6693911 | 0.73 | MMP13 (0.55) | MMP1MMP13MMP9MMP2MMP3 | |
| SCHEMBL6693872 | 0.72 | MMP1 (0.42) | MMP1MMP13MMP9MMP2MMP3 | |
| SCHEMBL6693302 | 0.71 | MMP13 (0.55) | MMP1MMP13MMP9MMP2MMP3 | |
| SCHEMBL6694302 | 0.70 | MMP1 (0.44) | MMP1MMP13MMP9MMP2MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1134215-B1 | 2-oxo-imidazolidine-4-carboxylic acid hydroxamine compounds that inhibit matrix metalloproteinases | PFIZER PROD INC (US) | 2004-10-06 | — | — | EP | claimed |