Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 7/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CMA1 | P23946 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.33 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.33 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6689698 | 0.81 | L3MBTL1 (0.41) | NOTUML3MBTL1CMA1KEAP1POLB | |
| SCHEMBL6164712 | 0.76 | L3MBTL1 (0.38) | NOTUML3MBTL1POLBMAPK9MAPK10 | |
| SCHEMBL27603769 | 0.72 | NOTUM (0.44) | NOTUML3MBTL1KEAP1MAPK10 | |
| SCHEMBL6608216 | 0.71 | L3MBTL1 (0.41) | L3MBTL1POLB | |
| SCHEMBL6623169 | 0.71 | NOTUM (0.54) | NOTUMKEAP1 | |
| SCHEMBL7115204 | 0.70 | KMO (0.36) | — | |
| SCHEMBL17336682 | 0.70 | POLB (0.39) | POLB | |
| SCHEMBL27603765 | 0.70 | L3MBTL1 (0.42) | L3MBTL1POLB | |
| SCHEMBL6164277 | 0.69 | L3MBTL1 (0.36) | NOTUML3MBTL1POLBMAPK9MAPK10 | |
| SCHEMBL17336772 | 0.69 | POLB (0.38) | L3MBTL1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379511-A1 | DIHYDRO-BENZO (b) (1, 4) DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II | F. HOFFMANN-LA ROCHE AG (CH) | 2004-01-14 | — | — | EP | disclosed |
| WO-2002083652-A1 | DIHYDRO-BENZO [b] [1, 4] DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II | F. HOFFMANN-LA ROCHE AG (CH) | 2002-10-24 | — | — | WO | disclosed |