Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.40 |
| ▸ | CMA1 | P23946 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6608216 | 0.90 | L3MBTL1 (0.41) | L3MBTL1POLBKMT2AMEN1ALDH1A1 | |
| SCHEMBL6164712 | 0.89 | L3MBTL1 (0.38) | L3MBTL1POLBNOTUMMAPK9MAPK10 | |
| SCHEMBL6624416 | 0.85 | POLB (0.40) | L3MBTL1POLBKMT2AMEN1ALDH1A1 | |
| SCHEMBL6626827 | 0.83 | HSD11B1 (0.40) | L3MBTL1POLBKMT2AMEN1ALDH1A1 | |
| SCHEMBL6168682 | 0.83 | TP53 (0.40) | L3MBTL1POLBALDH1A1 | |
| SCHEMBL6164277 | 0.82 | L3MBTL1 (0.36) | L3MBTL1POLBNOTUMKMT2AMEN1 | |
| SCHEMBL6689705 | 0.81 | NOTUM (0.39) | L3MBTL1POLBNOTUMCMA1KEAP1 | |
| SCHEMBL6166867 | 0.81 | L3MBTL1 (0.36) | L3MBTL1POLBNOTUMMAPK9MAPK10 | |
| SCHEMBL27615910 | 0.80 | POLB (0.43) | POLB | |
| SCHEMBL6434623 | 0.80 | NOTUM (0.39) | L3MBTL1POLBNOTUMCMA1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379511-A1 | DIHYDRO-BENZO (b) (1, 4) DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II | F. HOFFMANN-LA ROCHE AG (CH) | 2004-01-14 | — | — | EP | disclosed |
| WO-2002083652-A1 | DIHYDRO-BENZO [b] [1, 4] DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II | F. HOFFMANN-LA ROCHE AG (CH) | 2002-10-24 | — | — | WO | disclosed |