Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KAT6A | Q92794 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | TEK | Q02763 | 1/20 | 0.36 |
| ▸ | GLS | O94925 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6689698 | 0.90 | L3MBTL1 (0.41) | L3MBTL1POLBMEN1ALDH1A1KMT2A | |
| SCHEMBL6166140 | 0.89 | L3MBTL1 (0.38) | L3MBTL1POLBKAT6ALMNANTRK1 | |
| SCHEMBL6624416 | 0.87 | POLB (0.40) | L3MBTL1POLBMEN1ALDH1A1KMT2A | |
| SCHEMBL6624974 | 0.87 | KAT6A (0.40) | L3MBTL1KAT6ALMNATEKGLS | |
| SCHEMBL27603765 | 0.85 | L3MBTL1 (0.42) | L3MBTL1POLBKAT6ALMNATEK | |
| SCHEMBL6168682 | 0.83 | TP53 (0.40) | L3MBTL1POLBLMNAALDH1A1 | |
| SCHEMBL6164072 | 0.82 | L3MBTL1 (0.36) | L3MBTL1POLBKAT6ALMNASYK | |
| SCHEMBL27615910 | 0.80 | POLB (0.43) | POLB | |
| SCHEMBL6434059 | 0.80 | POLB (0.37) | L3MBTL1POLBKAT6ALMNANTRK1 | |
| SCHEMBL6626827 | 0.79 | HSD11B1 (0.40) | L3MBTL1POLBNTRK1MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379511-A1 | DIHYDRO-BENZO (b) (1, 4) DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II | F. HOFFMANN-LA ROCHE AG (CH) | 2004-01-14 | — | — | EP | disclosed |
| WO-2002083652-A1 | DIHYDRO-BENZO [b] [1, 4] DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II | F. HOFFMANN-LA ROCHE AG (CH) | 2002-10-24 | — | — | WO | disclosed |