Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 4/20 | 0.53 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.53 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.45 |
| ▸ | BAD | Q92934 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | CMA1 | P23946 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.44 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6896629 | 0.89 | MAPK8 (0.47) | MAPK8MAPK9MAPK10MAPTMCL1 | |
| SCHEMBL6895068 | 0.88 | MAPK8 (0.47) | MAPK8MAPK9MAPK10MAPTMCL1 | |
| SCHEMBL6896536 | 0.88 | MAPK8 (0.47) | MAPK8MAPK9MAPK10MAPTMCL1 | |
| SCHEMBL6894579 | 0.87 | MAPK8 (0.45) | MAPK8MAPK9MAPK10MAPTMCL1 | |
| SCHEMBL6689180 | 0.86 | LMNA (0.47) | MAPTKDM4ELMNATSHRPLA2G2A | |
| SCHEMBL6690888 | 0.86 | MEN1 (0.47) | MAPK8MAPTMCL1BADKDM4E | |
| SCHEMBL6889876 | 0.85 | MAPK8 (0.44) | MAPK8MAPK9MAPK10MAPTMCL1 | |
| SCHEMBL6688455 | 0.85 | MAPT (0.48) | MAPTKDM4ELMNATSHRPLA2G2A | |
| SCHEMBL6691803 | 0.85 | LMNA (0.47) | MAPTKDM4ELMNATSHRALDH1A1 | |
| SCHEMBL6888996 | 0.85 | TSHR (0.46) | MAPK8MAPK9MAPK10KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0952149-B1 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | LILLY CO ELI (US) | 2004-06-09 | — | — | EP | disclosed |
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |