Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 3/20 | 0.47 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 8/20 | 0.46 |
| ▸ | BAD | Q92934 | 8/20 | 0.46 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.44 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CMA1 | P23946 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6889876 | 0.92 | MAPK8 (0.44) | MAPK8MAPK9MAPK10MCL1BAD | |
| SCHEMBL6896629 | 0.89 | MAPK8 (0.47) | MAPK8MAPK9MAPK10MCL1BAD | |
| SCHEMBL6690168 | 0.88 | MAPK8 (0.53) | MAPK8MAPK9MAPK10MCL1BAD | |
| SCHEMBL6896536 | 0.88 | MAPK8 (0.47) | MAPK8MAPK9MAPK10MCL1BAD | |
| SCHEMBL6891733 | 0.88 | MAPT (0.43) | PLA2G2AMAPTKDM4EGAAMEN1 | |
| SCHEMBL6775459 | 0.88 | MCL1 (0.48) | MAPK8MCL1BADPLA2G1BPLA2G2A | |
| SCHEMBL6894747 | 0.88 | PLA2G2A (0.44) | MCL1BADPLA2G1BPLA2G2AMAPT | |
| SCHEMBL6894204 | 0.87 | L3MBTL1 (0.44) | MAPTKDM4EGAAMEN1KMT2A | |
| SCHEMBL6894916 | 0.87 | MAPT (0.45) | PLA2G2AMAPTKDM4EGAAMEN1 | |
| SCHEMBL6894500 | 0.87 | PTGDR2 (0.39) | MAPK8KDM4EMEN1KMT2ANR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |