Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CMA1 | P23946 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 6/20 | 0.46 |
| ▸ | BAD | Q92934 | 6/20 | 0.46 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.45 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | F10 | P00742 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | CD38 | P28907 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31511324 | 0.89 | MEN1 (0.50) | MEN1KMT2ACMA1MCL1BAD | |
| SCHEMBL7425661 | 0.89 | MEN1 (0.50) | MEN1KMT2ACMA1MCL1BAD | |
| SCHEMBL6781636 | 0.88 | MCL1 (0.45) | MEN1KMT2ACMA1MCL1BAD | |
| SCHEMBL6775459 | 0.88 | MCL1 (0.48) | MEN1KMT2ACMA1MCL1BAD | |
| SCHEMBL6776083 | 0.86 | PLA2G1B (0.42) | MEN1KMT2ACMA1MCL1BAD | |
| SCHEMBL6690168 | 0.86 | MAPK8 (0.53) | MEN1KMT2ACMA1MCL1BAD | |
| SCHEMBL6775683 | 0.85 | PLA2G1B (0.41) | MEN1KMT2ACMA1MCL1BAD | |
| SCHEMBL6776015 | 0.84 | MCL1 (0.44) | MEN1KMT2ACMA1MCL1BAD | |
| SCHEMBL6691170 | 0.84 | PLA2G2A (0.46) | MEN1KMT2APLA2G2AKDM4EAURKA | |
| SCHEMBL6774411 | 0.84 | AURKA (0.41) | MEN1KMT2APLA2G2AKDM4EAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0952149-B1 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | LILLY CO ELI (US) | 2004-06-09 | — | — | EP | disclosed |
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |