Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 3/20 | 0.47 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 6/20 | 0.42 |
| ▸ | BAD | Q92934 | 6/20 | 0.42 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.42 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.42 |
| ▸ | CMA1 | P23946 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6690168 | 0.89 | MAPK8 (0.53) | MAPK8MAPK9MAPK10MAPTKDM4E | |
| SCHEMBL6896536 | 0.89 | MAPK8 (0.47) | MAPK8MAPK9MAPK10MAPTKDM4E | |
| SCHEMBL6895068 | 0.89 | MAPK8 (0.47) | MAPK8MAPK9MAPK10MAPTKDM4E | |
| SCHEMBL6781636 | 0.89 | MCL1 (0.45) | KDM4EMCL1BADPLA2G1BPLA2G2A | |
| SCHEMBL6892544 | 0.89 | MAPT (0.44) | MAPTKDM4EPLA2G2AKMT2AALDH1A1 | |
| SCHEMBL6894579 | 0.87 | MAPK8 (0.45) | MAPK8MAPK9MAPK10MAPTKDM4E | |
| SCHEMBL6898392 | 0.87 | L3MBTL1 (0.44) | MAPTKDM4EKMT2AALDH1A1MEN1 | |
| SCHEMBL6894986 | 0.87 | HSP90AA1 (0.38) | MAPTKDM4EKMT2AALDH1A1HPGD | |
| SCHEMBL6897295 | 0.87 | MAPT (0.48) | MAPTKDM4EPLA2G2AKMT2AALDH1A1 | |
| SCHEMBL6889876 | 0.85 | MAPK8 (0.44) | MAPK8MAPK9MAPK10MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |