Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H3 | Q13133 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6567211 | 0.78 | RAB9A (0.42) | NR1H3MAOBRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL6512194 | 0.76 | NR1H3 (0.60) | NR1H3SMN1; SMN2ALDH1A1MEN1MAPT | |
| SCHEMBL6936421 | 0.75 | NR1H3 (0.49) | NR1H3ALDH1A1OPRM1OPRK1 | |
| SCHEMBL4086901 | 0.69 | ALOX15 (0.56) | NR1H3MAOBRAB9AKDM4ELMNA | |
| SCHEMBL4086772 | 0.67 | KDM4E (0.52) | NR1H3MAOBRAB9AKDM4ELMNA | |
| SCHEMBL6566919 | 0.65 | NR1H3 (0.44) | NR1H3MAOBRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL203431 | 0.65 | PRSS1 (0.67) | F10KMT2AOPRM1OPRD1 | |
| SCHEMBL204344 | 0.64 | NR4A2 (0.56) | KMT2AOPRM1OPRD1OPRK1KCNH2 | |
| SCHEMBL30344364 | 0.64 | PARP1 (0.57) | SMN1; SMN2KDM4ELMNAF10ALDH1A1 | |
| SCHEMBL7451728 | 0.64 | SIRT2 (0.60) | MAOBF10KMT2AOPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2004509161-A | — | — | 2004-03-25 | — | — | JP | claimed |
| EP-1318976-A2 | SUBSTITUTED AMINOPROPOXYARYL DERIVATIVES USEFUL AS AGONISTS FOR LXR | GLAXO GROUP LIMITED (GB) | 2003-06-18 | — | — | EP | claimed |
| WO-2002024632-A2 | SUBSTITUTED AMINOPROPOXYARYL DERIVATIVES USEFUL AS AGONISTS FOR LXR | GLAXO GROUP LIMITED (GB) | 2002-03-28 | — | — | WO | claimed |