Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | F10 | P00742 | 2/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | PLG | P00747 | 1/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.35 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.35 |
| ▸ | C1S | P09871 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6566919 | 0.83 | NR1H3 (0.44) | RAB9ASMN1; SMN2NPC1TP53F10 | |
| SCHEMBL6690258 | 0.78 | NR1H3 (0.40) | RAB9ASMN1; SMN2NPC1TP53F10 | |
| SCHEMBL6512194 | 0.77 | NR1H3 (0.60) | SMN1; SMN2NR1H3MEN1KMT2AALDH1A1 | |
| SCHEMBL6567234 | 0.68 | NR1H3 (0.47) | SMN1; SMN2F10NR1H3F2PLG | |
| SCHEMBL203431 | 0.67 | PRSS1 (0.67) | F10OPRM1OPRD1F2PLG | |
| SCHEMBL6566864 | 0.66 | NR1H3 (0.49) | RAB9ASMN1; SMN2F10NR1H3MAOB | |
| SCHEMBL3979585 | 0.66 | PRSS1 (0.65) | F2PLGPRSS1PRSS2C1S | |
| SCHEMBL10990677 | 0.66 | KDM4E (0.53) | SMN1; SMN2F10MAOBPRSS1KDM4E | |
| SCHEMBL30343815 | 0.66 | F10 (0.57) | RAB9ASMN1; SMN2NPC1F10LMNA | |
| SCHEMBL1387303 | 0.64 | OPRM1 (0.59) | RAB9ANPC1LMNAMAOBOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1318976-B1 | SUBSTITUTED AMINOPROPOXYARYL DERIVATIVES USEFUL AS AGONISTS FOR LXR | GLAXO GROUP LTD (GB) | 2004-11-24 | — | — | EP | claimed |