Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.46 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.43 |
| ▸ | CHKA | P35790 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3226312 | 0.95 | ALDH1A1 (0.48) | HPGDTSHRKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL6687780 | 0.91 | PARP1 (0.46) | HPGDTSHRKMT2AGRIN2BPLA2G7 | |
| SCHEMBL6687434 | 0.89 | HPGD (0.44) | HPGDTSHRKMT2AHRH3GRIN2B | |
| SCHEMBL6688446 | 0.86 | PARP1 (0.46) | HPGDTSHRKMT2AHRH3GRIN2B | |
| SCHEMBL3234941 | 0.86 | ALDH1A1 (0.49) | HPGDTSHRKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL6690538 | 0.85 | HPGD (0.50) | HPGDTSHRKMT2AHRH3GRIN2B | |
| SCHEMBL6688045 | 0.81 | PARP1 (0.54) | HPGDTSHRKMT2AHRH3GRIN2B | |
| SCHEMBL3231384 | 0.80 | KMT2A (0.56) | HPGDTSHRKMT2AALDH1A1MEN1 | |
| SCHEMBL2377312 | 0.79 | ALDH1A1 (0.50) | HPGDTSHRKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL3226386 | 0.77 | ALDH1A1 (0.56) | HPGDKMT2AALDH1A1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004074438-A2 | CCR8 ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-09-02 | — | — | WO | claimed |
| WO-2004074438-A2 | CCR8 ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-09-02 | — | — | WO | disclosed |