Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.44 |
| ▸ | CHKA | P35790 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.43 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.43 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6687434 | 0.93 | HPGD (0.44) | PARP1HPGDKMT2AMEN1TSHR | |
| SCHEMBL6690537 | 0.91 | HPGD (0.48) | PARP1HPGDKMT2AMEN1TSHR | |
| SCHEMBL6687783 | 0.86 | HPGD (0.48) | PARP1HPGDKMT2AMEN1TSHR | |
| SCHEMBL3226312 | 0.85 | ALDH1A1 (0.48) | HPGDKMT2AMEN1TSHRALDH1A1 | |
| SCHEMBL6688446 | 0.84 | PARP1 (0.46) | PARP1HPGDKMT2ATSHRGRIN2B | |
| SCHEMBL6927393 | 0.82 | PARP1 (0.56) | PARP1HPGDKMT2AMEN1TSHR | |
| SCHEMBL3231384 | 0.81 | KMT2A (0.56) | HPGDKMT2AMEN1TSHRALDH1A1 | |
| SCHEMBL6697097 | 0.81 | PARP1 (0.42) | PARP1HPGDKMT2AMEN1TSHR | |
| SCHEMBL6692407 | 0.79 | KMT2A (0.54) | HPGDKMT2AMEN1TSHRALDH1A1 | |
| SCHEMBL6687439 | 0.79 | HPGD (0.46) | PARP1HPGDKMT2AMEN1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004074438-A2 | CCR8 ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-09-02 | — | — | WO | claimed |
| WO-2004074438-A2 | CCR8 ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-09-02 | — | — | WO | disclosed |