Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 17/20 | 0.42 |
| ▸ | RXRB | P28702 | 4/20 | 0.41 |
| ▸ | RXRG | P48443 | 4/20 | 0.41 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
| ▸ | HNF4A | P41235 | 4/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.39 |
| ▸ | RARA | P10276 | 3/20 | 0.38 |
| ▸ | RARB | P10826 | 3/20 | 0.38 |
| ▸ | RARG | P13631 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6674718 | 0.81 | RXRA (0.45) | RXRARXRBRXRGPDE5AHNF4A | |
| SCHEMBL8459590 | 0.81 | RXRA (0.45) | RXRARXRBRXRGPDE5AHNF4A | |
| SCHEMBL6688781 | 0.76 | RXRA (0.55) | RXRARXRBRXRGHNF4APPARG | |
| SCHEMBL6674082 | 0.75 | PDE5A (0.37) | RXRARXRBRXRGPDE5ARARA | |
| SCHEMBL8460248 | 0.75 | PDE5A (0.37) | RXRARXRBRXRGPDE5ARARA | |
| SCHEMBL6687824 | 0.73 | RXRA (0.47) | RXRAHNF4APPARGNR1H3 | |
| SCHEMBL4960820 | 0.72 | RXRA (0.52) | RXRARXRBRXRGHNF4APPARG | |
| SCHEMBL4960828 | 0.72 | RXRA (0.52) | RXRARXRBRXRGHNF4APPARG | |
| SCHEMBL6915866 | 0.70 | RARA (0.64) | RXRARXRBRXRGHNF4APPARG | |
| SCHEMBL7124972 | 0.68 | RARA (0.61) | RXRARXRBRXRGHNF4APPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0862554-B1 | AROMATIC CARBOXYLIC ACID ESTERS, THE PRODUCTION OF SAME AND USE OF SAME AS MEDICAMENTS | HOFFMANN LA ROCHE (CH) | 2004-10-20 | — | — | EP | disclosed |
| EP-0862554-A1 | AROMATIC CARBOXYLIC ACID ESTERS, THE PRODUCTION OF SAME AND USE OF SAME AS MEDICAMENTS | F. HOFFMANN-LA ROCHE AG (CH) | 1998-09-09 | — | — | EP | disclosed |
| WO-1997018192-A1 | AROMATIC CARBOXYLIC ACID ESTERS, THE PRODUCTION OF SAME AND USE OF SAME AS MEDICAMENTS | F. HOFFMANN-LA ROCHE AG (CH) | 1997-05-22 | — | — | WO | disclosed |