Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | RXRA | P19793 | 7/20 | 0.33 |
| ▸ | RARA | P10276 | 2/20 | 0.32 |
| ▸ | RARB | P10826 | 2/20 | 0.32 |
| ▸ | RARG | P13631 | 2/20 | 0.32 |
| ▸ | RXRB | P28702 | 2/20 | 0.31 |
| ▸ | RXRG | P48443 | 2/20 | 0.31 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6674082 | 1.00 | PDE5A (0.37) | PDE5ARXRARARARARBRARG | |
| SCHEMBL6674718 | 0.78 | RXRA (0.45) | PDE5ARXRARARARARBRARG | |
| SCHEMBL8459590 | 0.78 | RXRA (0.45) | PDE5ARXRARARARARBRARG | |
| SCHEMBL6690730 | 0.75 | RXRA (0.42) | PDE5ARXRARARARARBRARG | |
| SCHEMBL2464113 | 0.74 | FAAH (0.41) | PDE5A | |
| SCHEMBL2495389 | 0.74 | FAAH (0.41) | PDE5A | |
| SCHEMBL6678267 | 0.69 | RXRA (0.43) | RXRARARARARBRARGRXRB | |
| SCHEMBL6678059 | 0.69 | RXRA (0.49) | RXRARARARARBRARGRXRB | |
| SCHEMBL4668099 | 0.69 | RXRA (0.37) | RXRARARARARBRARGCYP26A1 | |
| SCHEMBL6479338 | 0.67 | RXRA (0.47) | RXRARARARARBRARGRXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5958956-A | SKIN DISORDERS; WOUND HEALING AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1999-09-28 | — | — | US | disclosed |
| US-5726191-A | TREATEMENT OF LIGHT AND AGE DAMAGED SKIN | HOFFMANN-LA ROCHE INC. (US) | 1998-03-10 | — | — | US | disclosed |