Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | CCR2 | P41597 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.42 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6692683 | 0.85 | ALDH1A1 (0.50) | PKMGAATSHRCCR2ALDH1A1 | |
| SCHEMBL8861166 | 0.79 | TSHR (0.46) | PKMGAATSHRCCR2HPGD | |
| SCHEMBL17140103 | 0.77 | CCR2 (0.43) | TSHRCCR2ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL7883606 | 0.76 | POLB (0.46) | PKMGAATSHRRAB9ALMNA | |
| SCHEMBL7883305 | 0.74 | TSHR (0.44) | PKMGAATSHRCCR2HPGD | |
| SCHEMBL10844803 | 0.72 | KMT2A (0.55) | PKMGAATSHRNOTUMALDH1A1 | |
| SCHEMBL10844806 | 0.72 | MEN1 (0.51) | PKMGAAHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL23421379 | 0.72 | TSHR (0.52) | PKMGAATSHRHPGDRAB9A | |
| SCHEMBL8823072 | 0.71 | ALDH1A1 (0.51) | PKMGAATSHRCCR2HPGD | |
| SCHEMBL20534213 | 0.71 | LMNA (0.48) | TSHRHPGDRAB9AADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004108730-A1 | 1H-IMIDAZO`4,5-D!PYRIDAZINES AS DPP-IV INHIBITORS FOR THE TREATMENT OF NIDDM | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-12-16 | — | — | WO | disclosed |