Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 6/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.41 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.41 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | MGAM | O43451 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SI | P14410 | 1/20 | 0.37 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.37 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL31496494 | 0.85 | ALDH1A1 (0.52) | HCAR2ALDH1A1LMNAHSD17B10TSHR | |
| Maleic Acid SCHEMBL720767 | 0.83 | HCAR2 (0.57) | HCAR2ALDH1A1LMNAHSD17B10TSHR | |
| Ethyl Fumarate SCHEMBL27952657 | 0.83 | HCAR2 (0.83) | HCAR2ALDH1A1LMNAHSD17B10 | |
| Fumaric Acid SCHEMBL8953356 | 0.83 | HCAR2 (0.57) | HCAR2ALDH1A1LMNAHSD17B10TSHR | |
| Maleic Acid SCHEMBL15653018 | 0.83 | HCAR2 (0.57) | HCAR2ALDH1A1LMNAHSD17B10TSHR | |
| Ethyl Fumarate SCHEMBL8073557 | 0.82 | HCAR2 (0.74) | HCAR2ALDH1A1LMNAHSD17B10GLO1 | |
| SCHEMBL4899159 | 0.82 | HCAR2 (0.61) | HCAR2ALDH1A1LMNAHSD17B10TSHR | |
| SCHEMBL4895205 | 0.82 | HCAR2 (0.61) | HCAR2ALDH1A1LMNAHSD17B10TSHR | |
| SCHEMBL17300570 | 0.82 | HCAR2 (0.61) | HCAR2ALDH1A1LMNAHSD17B10TSHR | |
| Maleic Acid SCHEMBL6600336 | 0.81 | ALDH1A1 (0.70) | HCAR2ALDH1A1LMNAHSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040136921-A1 | Product containing a clear hair lotion sprayable as an aerosol spray | WELLA AKTIENGESELLSCHAFT (DE) | 2004-07-15 | — | — | US | disclosed |