Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | MMP12 | P39900 | 2/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.42 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.42 |
| ▸ | ADCY6 | O43306 | 2/20 | 0.42 |
| ▸ | ADCY3 | O60266 | 2/20 | 0.42 |
| ▸ | ADCY9 | O60503 | 2/20 | 0.42 |
| ▸ | ADCY5 | O95622 | 2/20 | 0.42 |
| ▸ | ADCY8 | P40145 | 2/20 | 0.42 |
| ▸ | GCGR | P47871 | 2/20 | 0.42 |
| ▸ | ADCY7 | P51828 | 2/20 | 0.42 |
| ▸ | ADCY2 | Q08462 | 2/20 | 0.42 |
| ▸ | ADCY1 | Q08828 | 2/20 | 0.42 |
| ▸ | ADCY4 | Q8NFM4 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1687727 | 0.80 | CYP2D6 (0.48) | MAOBMAOAHDAC3LMNACYP2D6 | |
| SCHEMBL7663044 | 0.76 | GABBR2 (0.56) | HDAC3MMP12MMP2MMP9CYSLTR2 | |
| SCHEMBL6070813 | 0.75 | FLT3 (0.51) | MAOBMMP12MMP13LMNATAS1R3 | |
| SCHEMBL27688433 | 0.75 | GABBR2 (0.54) | MMP12MMP2MMP9CYSLTR2CYSLTR1 | |
| SCHEMBL3242852 | 0.75 | GABBR2 (0.54) | MMP12MMP2MMP9CYSLTR2CYSLTR1 | |
| SCHEMBL4403980 | 0.75 | GABBR2 (0.54) | MMP12MMP2MMP9CYSLTR2CYSLTR1 | |
| SCHEMBL14576645 | 0.74 | MAOB (0.53) | MAOBMAOAHDAC3LMNAKDM4E | |
| SCHEMBL9185451 | 0.74 | CYP2C9 (0.50) | MMP12MMP2MMP9CYSLTR2CYSLTR1 | |
| SCHEMBL669582 | 0.74 | RAB9A (0.45) | LMNA | |
| SCHEMBL11479308 | 0.74 | ADCY6 (0.58) | MAOBMMP12MMP13ADCY6ADCY3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2349999-B1 | ALLOSTERIC PROTEIN KINASE MODULATORS | UNIV SAARLAND (DE) | 2016-01-27 | — | — | EP | disclosed |
| US-8912186-B2 | Allosteric protein kinase modulators | UNIVERSITAET DES SAARLANDES (DE) | 2014-12-16 | — | — | US | disclosed |
| US-20120046307-A1 | ALLOSTERIC PROTEIN KINASE MODULATORS | UNIVERSITAET DES SAARLANDES (DE) | 2012-02-23 | — | — | US | disclosed |
| EP-2349999-A1 | ALLOSTERIC PROTEIN KINASE MODULATORS | Universität des Saarlandes (DE) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010043711-A1 | ALLOSTERIC PROTEIN KINASE MODULATORS | UNIVERSITAET DES SAARLANDES (DE) | 2010-04-22 | — | — | WO | disclosed |
| EP-2177510-A1 | Allosteric protein kinase modulators | Universität des Saarlandes (DE) | 2010-04-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046307-A1 | ALLOSTERIC PROTEIN KINASE MODULATORS | AURKC, AURKA, AURKB | MAOB 4512/4885MAOA 4177/4885HDAC3 2060/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.