Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.52 |
| ▸ | IKBKB | O14920 | 1/20 | 0.51 |
| ▸ | CHEK2 | O96017 | 15/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | SNCA | P37840 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11485417 | 0.84 | PARP1 (0.52) | PARP1IKBKBCHEK2MEN1KMT2A | |
| SCHEMBL6691823 | 0.83 | PIN1 (0.56) | PARP1IKBKBCHEK2MEN1KMT2A | |
| SCHEMBL3993126 | 0.79 | DGAT1 (0.51) | PARP1CHEK2GAAMAPTHSD17B10 | |
| SCHEMBL6691354 | 0.79 | PARP1 (0.56) | PARP1CHEK2NPC1ALDH1A1GAA | |
| SCHEMBL10694623 | 0.79 | PARP1 (0.51) | PARP1IKBKBCHEK2MEN1KMT2A | |
| SCHEMBL3997493 | 0.78 | KDM4E (0.54) | PARP1CHEK2KDM4ENPC1ALDH1A1 | |
| SCHEMBL5126528 | 0.76 | MEN1 (0.55) | CHEK2MEN1KMT2A | |
| SCHEMBL8964072 | 0.71 | PIN1 (0.55) | PARP1CHEK2MEN1KMT2AKDM4E | |
| SCHEMBL11481631 | 0.70 | PARP1 (0.52) | PARP1CHEK2ALDH1A1GAAHPGD | |
| SCHEMBL11470960 | 0.69 | CHEK2 (0.48) | PARP1IKBKBCHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040006118-A1 | Nf-kb inhibitors | SMITHKLINE BEECHAM CORPORATION | 2004-01-08 | — | — | US | claimed |
| EP-1328272-A1 | NF-KAPPA-B INHIBITORS | SmithKline Beecham Corporation (US) | 2003-07-23 | — | — | EP | claimed |
| WO-2002030423-A1 | NF-λB INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-04-18 | — | — | WO | claimed |
| US-20040006118-A1 | Nf-kb inhibitors | SMITHKLINE BEECHAM CORPORATION | 2004-01-08 | — | — | US | disclosed |
| EP-1328272-A1 | NF-KAPPA-B INHIBITORS | SmithKline Beecham Corporation (US) | 2003-07-23 | — | — | EP | disclosed |
| WO-2002030423-A1 | NF-λB INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-04-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040006118-A1 | Nf-kb inhibitors | NFKBIA, IKBKB, IKBKG | PARP1 1567/4885IKBKB 2/4885CHEK2 299/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.