SCHEMBL669217

SCHEMBL669217

[PbH2].c1ccc2c(c1)cc[n+]1ccccc21

nearest known ligand 0.40

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.40
HSD17B10 Q99714 2/20 0.40
CYP2A6 P11509 1/20 0.40
TSHR P16473 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
CHAT P28329 4/20 0.39
HPRT1 P00492 1/20 0.37
HIF1A Q16665 1/20 0.34
CYP1B1 Q16678 1/20 0.34
CYP1A2 P05177 1/20 0.34
CYP2C9 P11712 1/20 0.34
CYP2C19 P33261 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL610868 0.98 ALDH1A1 (0.42) ALDH1A1HSD17B10CYP2A6TSHRTDP1
SCHEMBL669216 0.96 ALDH1A1 (0.40) ALDH1A1HSD17B10CYP2A6TSHRTDP1
Methane SCHEMBL11666193 0.96 ALDH1A1 (0.40) ALDH1A1HSD17B10CYP2A6TSHRTDP1
SCHEMBL26063785 0.74 ESR1 (0.38) ALDH1A1
SCHEMBL27369540 0.72 ALDH1A1 (0.48) ALDH1A1HSD17B10CYP2A6TSHRTDP1
SCHEMBL4659202 0.71 ALDH1A1 (0.37) ALDH1A1HSD17B10CYP2A6TSHRTDP1
SCHEMBL31612244 0.71 ALDH1A1 (0.37) ALDH1A1HSD17B10CYP2A6TSHRTDP1
SCHEMBL11535969 0.69 ALDH1A1 (0.36) ALDH1A1HSD17B10CYP2A6TSHRTDP1
Hydrochloric Acid SCHEMBL7822399 0.69 ALDH1A1 (0.36) ALDH1A1HSD17B10CYP2A6TSHRTDP1
SCHEMBL9232381 0.69 POLB (0.38) ALDH1A1HSD17B10CYP2A6TSHRTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260103446-A1 CFTR REGULATORS AND METHODS OF USE THEREOF UNIV CALIFORNIA (US) 2026-04-16 US disclosed
EP-4019501-B1 CFTR REGULATORS AND METHODS OF USE THEREOF UNIV CALIFORNIA (US) 2026-02-04 EP disclosed
US-12503447-B2 CFTR regulators and methods of use thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2025-12-23 US disclosed
US-12391654-B2 CFTR regulators and methods of use thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2025-08-19 US disclosed
US-20250109113-A1 CFTR REGULATORS AND METHODS OF USE THEREOF THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2025-04-03 US disclosed
US-12065412-B2 CFTR regulators and methods of use thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2024-08-20 US disclosed
EP-4071140-B1 CFTR REGULATORS AND METHODS OF USE THEREOF UNIV CALIFORNIA (US) 2024-07-03 EP disclosed
US-20230357170-A1 CFTR REGULATORS AND METHODS OF USE THEREOF THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2023-11-09 US disclosed
CN-115710233-A Modulators of CFTR and methods of use thereof 加利福尼亚大学董事会 2023-02-24 CN disclosed
EP-4071140-A1 CFTR REGULATORS AND METHODS OF USE THEREOF The Regents of The University of California (US) 2022-10-12 EP disclosed
WO-2017112950-A1 CFTR REGULATORS AND METHODS OF USE THEREOF THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2017-06-29 WO disclosed
WO-2017112951-A1 CFTR REGULATORS AND METHODS OF USE THEREOF THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2017-06-29 WO disclosed
US-9120768-B2 Compositions and methods for treatment of cystic fibrosis and diseases associated with aberrant protein cellular processing THE HOSPITAL FOR SICK CHILDREN (CA) 2015-09-01 US disclosed
US-20130150422-A1 COMPOSITIONS AND METHODS FOR TREATMENT OF CYSTIC FIBROSIS AND DISEASES ASSOCIATED WITH ABERRANT PROTEIN CELLULAR PROCESSING THE HOSPITAL FOR SICK CHILDREN (CA) 2013-06-13 US disclosed
WO-2012021974-A1 COMPOSITIONS AND METHODS FOR TREATMENT OF CYSTIC FIBROSIS AND DISEASES ASSOCIATED WITH ABERRANT PROTEIN CELLULAR PROCESSING THE HOSPITAL FOR SICK CHILDREN (CA) 2012-02-23 WO disclosed
US-20060014940-A1 Cloning and characterization of slc26a6, slc26a1, and slc26a2 anion exchangers MOUNT DAVID B 2006-01-19 US disclosed
US-20050176945-A1 Cloning and characterization of slc26a7 and slc26a9 anion exchangers MOUNT JR DAVID B (US) 2005-08-11 US disclosed
WO-2003074664-A2 CLONING AND CHARACTERIZATION OF SLC26A7 AND SLC26A9 ANION EXCHANGERS VANDERBILT UNIVERSITY (US) 2003-09-12 WO disclosed
WO-2003072756-A2 CLONING AND CHARACTERIZATION OF SLC26A8 AND SLC26A11 ANION EXCHANGERS VANDERBILT UNIVERSITY (US) 2003-09-04 WO disclosed
WO-2003072759-A2 CLONING AND CHARACTERIZATION OF SLC26A6, SLC26A1, AND SLC26A2 ANION EXCHANGERS VANDERBILT UNIVERSITY (US) 2003-09-04 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130150422-A1 COMPOSITIONS AND METHODS FOR TREATMENT OF CYSTIC FIBROSIS AND DISEASES ASSOCIATED WITH ABERRANT PROTEIN CELLULAR PROCESSING CFTR, PTMS, CHAMP1 ALDH1A1 3291/4885HSD17B10 1396/4885CYP2A6 3005/4885
US-12065412-B2 CFTR regulators and methods of use thereof CFTR, SLC26A4, CLCN2 ALDH1A1 2135/4885HSD17B10 2372/4885CYP2A6 1317/4885
US-20230357170-A1 CFTR REGULATORS AND METHODS OF USE THEREOF CFTR, SLC26A4, CLCN2 ALDH1A1 2135/4885HSD17B10 2372/4885CYP2A6 1317/4885
US-12391654-B2 CFTR regulators and methods of use thereof CFTR, SLC26A4, CLCN2 ALDH1A1 2135/4885HSD17B10 2372/4885CYP2A6 1317/4885
US-20260103446-A1 CFTR REGULATORS AND METHODS OF USE THEREOF CFTR, CLCN2, SLC26A3 ALDH1A1 1179/4885HSD17B10 3094/4885CYP2A6 1013/4885
US-12503447-B2 CFTR regulators and methods of use thereof CFTR, SLC26A4, CLCN2 ALDH1A1 2135/4885HSD17B10 2372/4885CYP2A6 1317/4885
US-20250109113-A1 CFTR REGULATORS AND METHODS OF USE THEREOF CFTR, SLC26A4, CLCN2 ALDH1A1 2135/4885HSD17B10 2372/4885CYP2A6 1317/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.