Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD52 | P43351 | 7/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.63 |
| ▸ | POLB | P06746 | 3/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | WHR1 | P49842 | 2/20 | 0.61 |
| ▸ | MPO | P05164 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | SLC9A3 | P48764 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | STAT6 | P42226 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6692491 | 0.85 | KMT2A (0.67) | RAD52KMT2AALDH1A1MEN1MAPT | |
| SCHEMBL6695887 | 0.84 | ALDH1A1 (0.67) | RAD52KMT2AALDH1A1MEN1MAPT | |
| SCHEMBL6693942 | 0.80 | RAD52 (0.74) | RAD52KMT2AALDH1A1MEN1MAPT | |
| SCHEMBL6695249 | 0.80 | KDM4E (0.71) | RAD52KMT2AALDH1A1MEN1MAPT | |
| SCHEMBL6696586 | 0.80 | ALDH1A1 (0.60) | RAD52KMT2AALDH1A1MEN1MAPT | |
| SCHEMBL6695258 | 0.79 | RAD52 (0.72) | RAD52KMT2AALDH1A1MEN1MAPT | |
| SCHEMBL6693510 | 0.79 | RAD52 (1.00) | RAD52KMT2AALDH1A1MEN1MAPT | |
| SCHEMBL30759714 | 0.78 | WHR1 (0.71) | KDM4EWHR1L3MBTL1PDE3BPDE3A | |
| SCHEMBL1257435 | 0.78 | WHR1 (0.71) | KDM4EWHR1L3MBTL1PDE3BPDE3A | |
| SCHEMBL6695603 | 0.78 | RAD52 (0.74) | RAD52KMT2AALDH1A1MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040224965-A1 | 2-Guanidino-4-arylchinazolines as nhe-3 inhibitors | MERCK PATENT GMBH (DE) | 2004-11-11 | — | — | US | claimed |
| CN-1422260-A | 2-guanidino-4-arylchinazolines as NHE-3 inhibitors | MERCK PATENT GMBH (DE) | 2003-06-04 | — | — | CN | claimed |
| US-20040224965-A1 | 2-Guanidino-4-arylchinazolines as nhe-3 inhibitors | MERCK PATENT GMBH (DE) | 2004-11-11 | — | — | US | disclosed |
| CN-1422260-A | 2-guanidino-4-arylchinazolines as NHE-3 inhibitors | MERCK PATENT GMBH (DE) | 2003-06-04 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040224965-A1 | 2-Guanidino-4-arylchinazolines as nhe-3 inhibitors | NHERF1, SLC9A3, SLC9A1 | RAD52 4856/4885KMT2A 3326/4885ALDH1A1 875/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.