Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.67 |
| ▸ | RAD52 | P43351 | 5/20 | 0.67 |
| ▸ | MAPT | P10636 | 5/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.67 |
| ▸ | MPO | P05164 | 4/20 | 0.67 |
| ▸ | MEN1 | O00255 | 3/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.58 |
| ▸ | POLB | P06746 | 3/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | ACACA | Q13085 | 1/20 | 0.46 |
| ▸ | SLC9A3 | P48764 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6692491 | 0.91 | KMT2A (0.67) | ALDH1A1RAD52MAPTKMT2AMPO | |
| SCHEMBL6695603 | 0.87 | RAD52 (0.74) | ALDH1A1RAD52MAPTKMT2AMPO | |
| SCHEMBL6692415 | 0.84 | RAD52 (0.64) | ALDH1A1RAD52MAPTKMT2AMPO | |
| SCHEMBL6695258 | 0.83 | RAD52 (0.72) | ALDH1A1RAD52MAPTKMT2AMPO | |
| SCHEMBL6693510 | 0.81 | RAD52 (1.00) | ALDH1A1RAD52MAPTKMT2AMPO | |
| SCHEMBL6694553 | 0.81 | KMT2A (0.81) | ALDH1A1RAD52MAPTKMT2AMPO | |
| SCHEMBL30607075 | 0.80 | MPO (1.00) | ALDH1A1RAD52MAPTKMT2AMPO | |
| SCHEMBL21964141 | 0.80 | MPO (1.00) | ALDH1A1RAD52MAPTKMT2AMPO | |
| SCHEMBL6695249 | 0.76 | KDM4E (0.71) | ALDH1A1RAD52MAPTKMT2AMPO | |
| SCHEMBL6693942 | 0.76 | RAD52 (0.74) | ALDH1A1RAD52MAPTKMT2AMPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040224965-A1 | 2-Guanidino-4-arylchinazolines as nhe-3 inhibitors | MERCK PATENT GMBH (DE) | 2004-11-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040224965-A1 | 2-Guanidino-4-arylchinazolines as nhe-3 inhibitors | NHERF1, SLC9A3, SLC9A1 | ALDH1A1 875/4885RAD52 4856/4885MAPT 4292/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.