Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 10/20 | 0.44 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 2/20 | 0.36 |
| ▸ | TTK | P33981 | 2/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.36 |
| ▸ | INCENP | Q9NQS7 | 2/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | PTPRC | P08575 | 1/20 | 0.34 |
| ▸ | METAP2 | P50579 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6695727 | 0.78 | MCL1 (0.47) | TNKSTNKS2 | |
| SCHEMBL6692474 | 0.73 | PARP1 (0.39) | DHODHMAPTMETAP2 | |
| SCHEMBL16456315 | 0.72 | TNKS (0.52) | TNKSTNKS2MAPT | |
| SCHEMBL16456392 | 0.69 | TNKS (0.49) | TNKSTNKS2TTKAURKBINCENP | |
| SCHEMBL16455971 | 0.69 | TNKS (0.49) | TNKSTNKS2 | |
| SCHEMBL1887764 | 0.69 | GRIA1 (0.52) | TNKSDHODHMETAP2 | |
| SCHEMBL13314211 | 0.69 | ALDH1A1 (0.49) | MAPT | |
| Hydrochloric Acid SCHEMBL3566887 | 0.68 | ALDH1A1 (0.47) | MAPT | |
| SCHEMBL16160810 | 0.67 | ALDH1A1 (0.41) | TNKSTNKS2AURKATTKAURKB | |
| SCHEMBL16151424 | 0.67 | PKM (0.48) | TNKSTNKS2AURKATTKAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465626-A2 | PHARMACEUTICAL COMPOSITIONS COMPRISING DIHYDROPYRIDINONE COMPOUNDS AND AN IMMUNOREGULATORY OR AN ANTIINFLAMMATORY AGENT AND THEIR USES | Eisai Co., Ltd. (JP) | 2004-10-13 | — | — | EP | disclosed |
| WO-2003047577-A2 | PHARMACEUTICAL COMPOSITIONS COMPRISING DIHYDROPYRIDINONE COMPOUNDS AND AN IMMUNOREGULATORY OR AN ANTIINFLAMMATORY AGENT AND THEIR USES | EISAI CO LTD (JP) | 2003-06-12 | — | — | WO | disclosed |