Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 12/20 | 0.40 |
| ▸ | MMP9 | P14780 | 9/20 | 0.40 |
| ▸ | MMP13 | P45452 | 8/20 | 0.40 |
| ▸ | ADAM17 | P78536 | 7/20 | 0.40 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 5/20 | 0.38 |
| ▸ | MMP3 | P08254 | 3/20 | 0.38 |
| ▸ | MMP7 | P09237 | 2/20 | 0.38 |
| ▸ | MMP8 | P22894 | 2/20 | 0.38 |
| ▸ | MMP14 | P50281 | 2/20 | 0.38 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.38 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.35 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.35 |
| ▸ | MMP10 | P09238 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6691004 | 0.90 | MMP13 (0.46) | MMP1MMP9MMP13ADAM17MMP2 | |
| SCHEMBL6694302 | 0.83 | MMP1 (0.44) | MMP1MMP9MMP13ADAM17S1PR5 | |
| SCHEMBL6693372 | 0.77 | MMP1 (0.41) | MMP1MMP9MMP13ADAM17S1PR5 | |
| SCHEMBL6698909 | 0.75 | S1PR5 (0.40) | MMP1MMP9MMP13ADAM17S1PR5 | |
| SCHEMBL6690762 | 0.73 | MMP13 (0.48) | MMP1MMP9MMP13ADAM17MMP2 | |
| SCHEMBL6690306 | 0.72 | MMP1 (0.45) | MMP1MMP9MMP13ADAM17S1PR5 | |
| SCHEMBL6691197 | 0.70 | MMP1 (0.45) | MMP1MMP9MMP13ADAM17S1PR5 | |
| SCHEMBL7862161 | 0.70 | MMP1 (0.43) | MMP1MMP9MMP13ADAM17S1PR5 | |
| SCHEMBL6689106 | 0.69 | S1PR5 (0.41) | MMP1MMP9MMP13ADAM17S1PR5 | |
| SCHEMBL6689488 | 0.67 | MMP13 (0.53) | MMP1MMP9MMP13ADAM17MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1134215-B1 | 2-oxo-imidazolidine-4-carboxylic acid hydroxamine compounds that inhibit matrix metalloproteinases | PFIZER PROD INC (US) | 2004-10-06 | — | — | EP | claimed |