Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.41 |
| ▸ | CASP1 | P29466 | 2/20 | 0.40 |
| ▸ | CASP3 | P42574 | 2/20 | 0.40 |
| ▸ | CASP7 | P55210 | 2/20 | 0.40 |
| ▸ | CASP8 | Q14790 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.39 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6687664 | 0.84 | MAOB (0.59) | LMNACD274MAOBMAOAPARP15 | |
| SCHEMBL6687667 | 0.84 | MAOB (0.59) | LMNACD274MAOBMAOAPARP15 | |
| SCHEMBL6691050 | 0.83 | KMT2A (0.43) | LMNACD274MAOBMAOASMN1; SMN2 | |
| SCHEMBL6691044 | 0.83 | KMT2A (0.43) | LMNACD274MAOBMAOASMN1; SMN2 | |
| SCHEMBL6691043 | 0.81 | CD274 (0.51) | CD274MAOBPDCD1 | |
| SCHEMBL6685871 | 0.81 | CD274 (0.51) | CD274MAOBPDCD1 | |
| SCHEMBL6685476 | 0.81 | MAOB (0.47) | LMNACD274MAOBMAOASMN1; SMN2 | |
| SCHEMBL6685482 | 0.81 | MAOB (0.47) | LMNACD274MAOBMAOASMN1; SMN2 | |
| SCHEMBL6690944 | 0.78 | MAOB (0.48) | LMNACD274MAOBMAOATP53 | |
| SCHEMBL6685594 | 0.77 | SCN9A (0.50) | MAOBMAOAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004087125-A1 | AMINO ACID DERIVATIVES AS INHIBITORS OF MAMMALIAN SODIUM CHANNELS | IONIX PHARMACEUTICALS LIMITED (GB) | 2004-10-14 | — | — | WO | disclosed |