Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6749654 | 0.80 | SMN1; SMN2 (0.60) | L3MBTL1LMNASMN1; SMN2ALDH1A1KEAP1 | |
| SCHEMBL6690757 | 0.79 | AURKA (0.47) | L3MBTL1LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL6689327 | 0.77 | CCR2 (0.33) | LMNASMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL4061705 | 0.76 | ALDH1A1 (0.42) | LMNASMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL483343 | 0.75 | ALDH1A1 (0.43) | LMNASMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL5051601 | 0.72 | CA12 (0.46) | L3MBTL1LMNASMN1; SMN2ALDH1A1GAA | |
| SCHEMBL5697206 | 0.71 | TSHR (0.38) | L3MBTL1LMNASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL8558659 | 0.71 | ALDH1A1 (0.45) | ALDH1A1KMT2AATMGAATSHR | |
| SCHEMBL6693457 | 0.71 | LMNA (0.45) | L3MBTL1PRMT1LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL10332311 | 0.71 | ALDH1A1 (0.44) | LMNASMN1; SMN2ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140871-A4 | THROMBIN OR FACTOR XA INHIBITORS | BRISTOL MYERS SQUIBB PHARMA CO (US) | 2004-05-06 | — | — | EP | disclosed |
| EP-1140871-A1 | THROMBIN OR FACTOR XA INHIBITORS | Du Pont Pharmaceuticals Company (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000039108-A1 | THROMBIN OR FACTOR XA INHIBITORS | DU PONT PHARMACEUTICALS COMPANY (US) | 2000-07-06 | — | — | WO | disclosed |