SCHEMBL669406

SCHEMBL669406

C=CCc1nc2c(N)ncnc2[nH]1

nearest known ligand 0.40

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 5/20 0.40
ADORA1 P30542 4/20 0.40
ADORA3 P0DMS8 2/20 0.40
ADORA2B P29275 2/20 0.40
CDC7 O00311 1/20 0.36
DBF4 Q9UBU7 1/20 0.36
PI4KA P42356 4/20 0.35
PI4K2B Q8TCG2 4/20 0.35
PI4K2A Q9BTU6 4/20 0.35
PI4KB Q9UBF8 4/20 0.35
RET P07949 1/20 0.33
XDH P47989 1/20 0.33
LRRK2 Q5S007 1/20 0.33
ERAP1 Q9NZ08 1/20 0.33
MAP4K4 O95819 2/20 0.33
LMNA P02545 1/20 0.32
NUDT1 P36639 2/20 0.32
NPSR1 Q6W5P4 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL669407 0.79 PI4KA (0.56) ADORA2AADORA1PI4KAPI4K2BPI4K2A
SCHEMBL5066797 0.77 PI4KA (0.43) ADORA2AADORA1ADORA3ADORA2BPI4KA
SCHEMBL6683145 0.76 PI4KA (0.42) ADORA2AADORA1ADORA3ADORA2BPI4KA
SCHEMBL19686245 0.75 PI4KA (0.51) ADORA2AADORA1ADORA3ADORA2BPI4KA
SCHEMBL17060219 0.74 ADORA2A (0.37) ADORA2AADORA1ADORA3ADORA2BPI4KA
SCHEMBL6029471 0.73 PI4KA (0.47) ADORA2AADORA1ADORA3ADORA2BPI4KA
SCHEMBL17574489 0.73 MEN1 (0.43) ADORA2AADORA1ADORA3ADORA2BLMNA
SCHEMBL9668597 0.72 PI4KA (0.60) ADORA2AADORA1ADORA2BPI4KAPI4K2B
SCHEMBL1080357 0.72 CCNB2 (0.40)
SCHEMBL7211994 0.72 PI4KA (0.49) ADORA2AADORA1PI4KAPI4K2BPI4K2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 720 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9284343-B2 2′-O-aminooxymethyl nucleoside derivatives for use in the synthesis and modification of nucleosides, nucleotides and oligonucleotides THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2016-03-15 US claimed
WO-2013071079-A1 LIN28/LET-7 CRYSTAL STRUCTURES, PURIFICATION PROTOCOLS, AND MOLECULAR PROBES SUITABLE FOR SCREENING ASSAYS AND THERAPEUTICS PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2013-05-16 WO claimed
WO-2024151685-A1 RECOMBINANT NUCLEIC ACID MOLECULES AND THEIR USE IN WOUND HEALING BETH ISRAEL DEACONESS MEDICAL CENTER, INC. (US) 2024-07-18 WO disclosed
WO-2024151673-A2 RECOMBINANT NUCLEIC ACID MOLECULES AND THEIR USE IN WOUND HEALING PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2024-07-18 WO disclosed
US-20240238210-A1 POLYNUCLEOTIDES ENCODING CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR FOR THE TREATMENT OF CYSTIC FIBROSIS ARES CAPITAL CORPORATION, AS AGENT 2024-07-18 US disclosed
WO-2024151687-A1 GENETIC SWITCHES AND THEIR USE IN TREATING CANCER FLAGSHIP PIONEERING INNOVATIONS V, INC. (US) 2024-07-18 WO disclosed
US-20240238473-A1 RECOMBINANT NUCLEIC ACID MOLECULES AND THEIR USE IN WOUND HEALING PRESIDENT AND FELLOWS OF HARVARD COLLEGE 2024-07-18 US disclosed
EP-4392140-A1 IN VITRO TRANSCRIPTION TECHNOLOGIES BioNTech SE (DE) 2024-07-03 EP disclosed
WO-2024133160-A1 HEPATITIS B COMPOSITIONS GLAXOSMITHKLINE BIOLOGICALS SA (BE) 2024-06-27 WO disclosed
US-20240209068-A1 MUCOSAL EXPRESSION OF ANTIBODY STRUCTURES AND ISOTYPES BY MRNA MODERNATX, INC. (US) 2024-06-27 US disclosed
EP-4387596-A1 LOW-DOSE LYOPHILIZED RNA VACCINES AND METHODS FOR PREPARING AND USING THE SAME GlaxoSmithKline Biologicals SA (BE) 2024-06-26 EP disclosed
WO-2011005765-A1 BIOPROCESSING ALNYLAM PHARMACEUTICALS, INC. (US) 2011-01-13 WO disclosed
WO-2011005786-A2 COMPOSITIONS AND METHODS FOR ENHANCING PRODUCTION OF A BIOLOGICAL PRODUCT ALNYLAM PHARMACEUTICALS, INC. (US) 2011-01-13 WO disclosed
WO-2010101951-A1 NUCLEIC ACID CHEMICAL MODIFICATIONS ALNYLAM PHARMACEUTICALS, INC. (US) 2010-09-10 WO disclosed
WO-2009155504-A9 METHODS FOR THE MODULATION OF ANGIOGENESIS THE CHILDREN'S MEDICAL CENTER CORPORATION (US) 2010-04-08 WO disclosed
WO-2010011895-A1 ENHANCEMENT OF SIRNA SILENCING ACTIVITY USING UNIVERSAL BASES OR MISMATCHES IN THE SENSE STRAND ALNYLAM PHARMACEUTICALS, INC. (US) 2010-01-28 WO disclosed
WO-2009155504-A2 METHODS FOR THE MODULATION OF ANGIOGENESIS THE CHILDREN'S MEDICAL CENTER CORPORATION (US) 2009-12-23 WO disclosed
WO-2009149239-A1 METHODS OF MODULATING ANGIOGENESIS VIA TRPV4 CHILDREN'S MEDICAL CENTER CORPORATION (US) 2009-12-10 WO disclosed
WO-2009126933-A2 SITE-SPECIFIC DELIVERY OF NUCLEIC ACIDS BY COMBINING TARGETING LIGANDS WITH ENDOSOMOLYTIC COMPONENTS ALNYLAM PHARMACEUTICALS, INC. (US) 2009-10-15 WO disclosed
WO-2009120878-A2 NON-NATURAL RIBONUCLEOTIDES, AND METHODS OF USE THEREOF ALNYLAM PHARMACEUTICALS, INC. (US) 2009-10-01 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240209068-A1 MUCOSAL EXPRESSION OF ANTIBODY STRUCTURES AND ISOTYPES BY MRNA NSUN3, IGLV6-57, MRPS23 ADORA2A 4871/4885ADORA1 4867/4885ADORA3 4405/4885
US-20240238473-A1 RECOMBINANT NUCLEIC ACID MOLECULES AND THEIR USE IN WOUND HEALING CHI3L2, CHI3L1, FGF2 ADORA2A 3850/4885ADORA1 4204/4885ADORA3 2303/4885
US-20240238210-A1 POLYNUCLEOTIDES ENCODING CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR FOR THE TREATMENT OF CYSTIC FIBROSIS CFTR, SLC47A1, TMEM205 ADORA2A 2099/4885ADORA1 1501/4885ADORA3 1099/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.