SCHEMBL6694769

SCHEMBL6694769

N#Cc1cc(F)c(N)cc1Oc1ccc2ccccc2c1

nearest known ligand 0.53

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.53
RCE1 Q9Y256 1/20 0.53
LMNA P02545 1/20 0.47
MAPT P10636 1/20 0.47
HTT P42858 1/20 0.47
FNTA P49354 1/20 0.46
FNTB P49356 1/20 0.46
PGGT1B P53609 1/20 0.46
AR P10275 12/20 0.41
CYP19A1 P11511 1/20 0.41
PLA2G7 Q13093 1/20 0.40
MEN1 O00255 1/20 0.40
NPC1 O15118 1/20 0.40
RAB9A P51151 1/20 0.40
KMT2A Q03164 1/20 0.40
CA1 P00915 1/20 0.40
CA2 P00918 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6696596 0.88 AR (0.43) GAAMAPTARMEN1KMT2A
SCHEMBL6833436 0.80 GAA (0.53) GAAMAPTFNTAFNTBPGGT1B
SCHEMBL28288025 0.78 ALDH1A1 (0.53) GAARCE1LMNAMAPTHTT
SCHEMBL6700601 0.78 FNTA (0.43) GAARCE1FNTAFNTBPGGT1B
SCHEMBL28288026 0.76 GAA (0.53) GAARCE1LMNAMAPTHTT
SCHEMBL24824091 0.76 AR (0.51) AR
SCHEMBL24825914 0.76 AR (0.51) LMNAFNTAFNTBPGGT1BAR
SCHEMBL8132627 0.76 GAA (0.62) GAARCE1LMNAMAPTHTT
SCHEMBL7237707 0.75 GAA (0.45) GAARCE1LMNAMAPTHTT
SCHEMBL20510954 0.74 ALDH1A1 (0.57) GAARCE1LMNAMAPTHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040029735-A1 Substituted herbicidal phenyluracils ANDREE ROLAND (DE) 2004-02-12 US disclosed
US-6624120-B1 Such as 1-(4-cyano-2-fluoro-5-(6-methoxy-naphthalen-2-yl-oxy)-phenyl)-2,6-dioxo -1,2,3,6-tetrahydro-pyrimidine-4-carboxylic acid BAYER AKTIENGESELLSCHAFT (DE) 2003-09-23 US disclosed
CN-1356989-A Substituted herbicidal phenyluracils BAYER AG (DE) 2002-07-03 CN disclosed
EP-1192140-A1 SUBSTITUTED HERBICIDAL PHENYLURACILS Bayer Aktiengesellschaft (DE) 2002-04-03 EP disclosed
WO-2000078734-A1 SUBSTITUTED HERBICIDAL PHENYLURACILS BAYER AKTIENGESELLSCHAFT (DE) 2000-12-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040029735-A1 Substituted herbicidal phenyluracils DDT, MTX1, MTX2 GAA 529/4885RCE1 476/4885LMNA 3926/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.