Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 18/20 | 0.81 |
| ▸ | MMP13 | P45452 | 14/20 | 0.48 |
| ▸ | MMP9 | P14780 | 8/20 | 0.48 |
| ▸ | ADAM17 | P78536 | 7/20 | 0.48 |
| ▸ | MMP2 | P08253 | 3/20 | 0.48 |
| ▸ | MMP3 | P08254 | 3/20 | 0.48 |
| ▸ | MMP7 | P09237 | 3/20 | 0.48 |
| ▸ | MMP8 | P22894 | 3/20 | 0.48 |
| ▸ | MMP14 | P50281 | 3/20 | 0.48 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.48 |
| ▸ | MMP10 | P09238 | 1/20 | 0.48 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.47 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.47 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.46 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6818064 | 0.98 | MMP1 (0.78) | MMP1MMP13MMP9ADAM17MMP2 | |
| SCHEMBL6699509 | 0.92 | MMP1 (0.84) | MMP1MMP13MMP9ADAM17MMP2 | |
| SCHEMBL6809651 | 0.91 | MMP1 (0.68) | MMP1MMP13MMP9ADAM17MMP2 | |
| SCHEMBL26986 | 0.90 | MMP1 (1.00) | MMP1MMP13MMP9ADAM17MMP2 | |
| SCHEMBL6876444 | 0.89 | MMP1 (0.81) | MMP1MMP13MMP9ADAM17MMP2 | |
| SCHEMBL6691163 | 0.88 | MMP1 (0.65) | MMP1MMP13MMP9ADAM17MMP2 | |
| SCHEMBL25130 | 0.88 | MMP1 (0.96) | MMP1MMP13MMP9ADAM17MMP2 | |
| SCHEMBL3914710 | 0.88 | MMP1 (0.78) | MMP1MMP13MMP9ADAM17MMP2 | |
| SCHEMBL6813051 | 0.87 | MMP1 (0.94) | MMP1MMP13MMP9ADAM17MMP2 | |
| SCHEMBL7000070 | 0.84 | MMP1 (0.59) | MMP1MMP13MMP9ADAM17MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0952148-B1 | Cyclobutyl-aryloxyarylsulfonylamino hydroxamic acid derivatives | PFIZER PROD INC (US) | 2004-05-12 | — | — | EP | disclosed |
| US-6156798-A | Cyclobutyl-aryloxyarylsulfonylamino hydroxamic acid derivatives | PFIZER INC (US) | 2000-12-05 | — | — | US | disclosed |
| EP-0952148-A1 | Cyclobutyl-aryloxyarylsulfonylamino hydroxamic acid derivatives | Pfizer Products Inc. (US) | 1999-10-27 | — | — | EP | disclosed |