Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 14/20 | 0.84 |
| ▸ | MMP13 | P45452 | 12/20 | 0.50 |
| ▸ | MMP2 | P08253 | 10/20 | 0.50 |
| ▸ | MMP9 | P14780 | 6/20 | 0.50 |
| ▸ | MMP14 | P50281 | 6/20 | 0.50 |
| ▸ | MMP8 | P22894 | 5/20 | 0.50 |
| ▸ | MMP16 | P51512 | 2/20 | 0.50 |
| ▸ | MMP3 | P08254 | 5/20 | 0.48 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.44 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.44 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.43 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.43 |
| ▸ | PTGES | O14684 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6876444 | 0.98 | MMP1 (0.81) | MMP1MMP13MMP2MMP9MMP14 | |
| SCHEMBL26986 | 0.92 | MMP1 (1.00) | MMP1MMP13MMP2MMP9MMP14 | |
| SCHEMBL6695057 | 0.92 | MMP1 (0.81) | MMP1MMP13MMP2MMP9MMP14 | |
| SCHEMBL6873149 | 0.91 | MMP1 (0.70) | MMP1MMP13MMP2MMP9MMP14 | |
| SCHEMBL8502159 | 0.90 | MMP1 (0.69) | MMP1MMP13MMP2MMP9MMP14 | |
| SCHEMBL25130 | 0.89 | MMP1 (0.96) | MMP1MMP13MMP2MMP9MMP14 | |
| SCHEMBL6818064 | 0.89 | MMP1 (0.78) | MMP1MMP13MMP2MMP9MMP14 | |
| SCHEMBL3914710 | 0.89 | MMP1 (0.78) | MMP1MMP13MMP2MMP9MMP14 | |
| SCHEMBL6693057 | 0.89 | MMP1 (0.68) | MMP1MMP13MMP2MMP9MMP14 | |
| SCHEMBL6813051 | 0.89 | MMP1 (0.94) | MMP1MMP13MMP2MMP9MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0952148-B1 | Cyclobutyl-aryloxyarylsulfonylamino hydroxamic acid derivatives | PFIZER PROD INC (US) | 2004-05-12 | — | — | EP | disclosed |
| US-6156798-A | Cyclobutyl-aryloxyarylsulfonylamino hydroxamic acid derivatives | PFIZER INC (US) | 2000-12-05 | — | — | US | disclosed |
| EP-0952148-A1 | Cyclobutyl-aryloxyarylsulfonylamino hydroxamic acid derivatives | Pfizer Products Inc. (US) | 1999-10-27 | — | — | EP | disclosed |