SCHEMBL669782

SCHEMBL669782

CC(=O)Nc1ccc(I)cc1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 3/20 0.67
L3MBTL1 Q9Y468 3/20 0.67
HTT P42858 1/20 0.67
KMT2A Q03164 6/20 0.64
MEN1 O00255 4/20 0.64
ALDH1A1 P00352 3/20 0.64
MAPT P10636 3/20 0.64
CA12 O43570 2/20 0.64
CA1 P00915 2/20 0.64
CA2 P00918 2/20 0.64
CA9 Q16790 2/20 0.64
TDP1 Q9NUW8 1/20 0.64
BRD4 O60885 1/20 0.64
NR1I2 O75469 1/20 0.64
MB P02144 1/20 0.64
CYP1A1 P04798 1/20 0.64
CA3 P07451 1/20 0.64
CYP3A4 P08684 1/20 0.64
RARG P13631 1/20 0.64
TSHR P16473 1/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6036738 0.88 SMN1; SMN2 (0.53) SMN1; SMN2L3MBTL1HTTKMT2AMEN1
SCHEMBL19227686 0.88 MAPT (0.71) SMN1; SMN2L3MBTL1HTTKMT2AMEN1
SCHEMBL861674 0.87 SMN1; SMN2 (0.84) SMN1; SMN2L3MBTL1HTTKMT2AMEN1
SCHEMBL14336092 0.85 SMN1; SMN2 (0.56) SMN1; SMN2L3MBTL1HTTKMT2AMEN1
SCHEMBL19707415 0.80 CA12 (0.68) SMN1; SMN2KMT2AMEN1MAPTCA12
SCHEMBL3818831 0.80 SMN1; SMN2 (1.00) SMN1; SMN2L3MBTL1HTTKMT2AMEN1
SCHEMBL11158565 0.80 MAPT (0.83) SMN1; SMN2L3MBTL1HTTKMT2AMEN1
SCHEMBL8164496 0.79 RXFP1 (0.62) SMN1; SMN2L3MBTL1HTTKMT2AMEN1
SCHEMBL7094502 0.79 MAPT (0.62) HTTKMT2AMEN1ALDH1A1MAPT
SCHEMBL1488126 0.78 SMN1; SMN2 (0.70) SMN1; SMN2L3MBTL1HTTKMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 239 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113336786-B Diastereoselective polysubstituted naphthenic compound and preparation method thereof 南京工业大学 2022-10-18 CN claimed
CN-111484503-B Mikanolide derivative and preparation method and application thereof 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) 2022-05-27 CN claimed
CN-113336786-A Diastereoselective polysubstituted naphthenic compound and preparation method thereof 南京工业大学 2021-09-03 CN claimed
CN-108017557-B Cyanidation method for preparing nitrile compound 中国科学院兰州化学物理研究所苏州研究院 2020-11-24 CN claimed
CN-111499566-A Pyridine derivative compound and preparation method thereof 南京工业大学 2020-08-07 CN claimed
CN-111484503-A Mikanolide derivative and preparation method and application thereof 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) 2020-08-04 CN claimed
US-7122694-B2 Hydroboronation process BORON MOLECULAR PTY LIMITED (AU) 2006-10-17 US claimed
US-20040133028-A1 Hydroboronation process COMMONWEALTH SCIENTIFIC 2004-07-08 US claimed
EP-1127060-B1 HYDROBORONATION PROCESS COMMW SCIENT IND RES ORG (AU) 2004-04-07 EP claimed
US-20020015826-A1 Zwitterionic iodonium compounds and methods of application CLEMSON UNIVERSITY 2002-02-07 US claimed
JP-60056928-A None JP disclosed
US-12325696-B2 Indazole derivative, preparation method therefor, and pharmaceutical application thereof JIANGSU HENGRUI MEDICINE CO., LTD. (CN) 2025-06-10 US disclosed
CN-120004934-A Preparation method of benzo-silicon-containing octatomic ring compound 郑州大学 2025-05-16 CN disclosed
CN-119320379-A Indazole derivative, preparation method and medical application thereof 江苏恒瑞医药股份有限公司 2025-01-17 CN disclosed
US-20240325573-A1 X-RAY DEVELOPABLE MOLECULE, EMBOLISM MICROSPHERE AND PREPARATION METHODS THEREFOR SHANGHAI HUIHE HEALTHCARE TECHNOLOGY CO., LTD. (CN) 2024-10-03 US disclosed
US-4990505-A Treating asthma, bronchitis; adrenergic stimulants GLAXO GROUP LIMITED (GB) 1991-02-05 US disclosed
EP-0391212-A2 Process for preparing bifunctional Z-stilbene compounds, new bifunctional Z-stilbene compounds and their use for preparing polymers BAYER AG (DE) 1990-10-10 EP disclosed
US-4567280-A NITROGEN DIOXIDE; BY-PRODUCT INHIBITION UBE INDUSTRIES, LTD. (JP) 1986-01-28 US disclosed
JP-S6056928-A PRODUCTION OF AROMATIC IODINE COMPOUND UBE IND LTD 1985-04-02 JP disclosed
US-4186153-A Process for 1,2,4,5-tetrachlorobenzene THE DOW CHEMICAL COMPANY (US) 1980-01-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020015826-A1 Zwitterionic iodonium compounds and methods of application DGKI, DSTN, PCNA SMN1; SMN2 3658/4885L3MBTL1 3773/4885HTT 2915/4885
US-20240325573-A1 X-RAY DEVELOPABLE MOLECULE, EMBOLISM MICROSPHERE AND PREPARATION METHODS THEREFOR F11, FAR1, FGB SMN1; SMN2 4879/4885L3MBTL1 1061/4885HTT 3530/4885
US-20040133028-A1 Hydroboronation process ALKBH3, HPD, HVCN1 SMN1; SMN2 4416/4885L3MBTL1 1650/4885HTT 588/4885
US-12325696-B2 Indazole derivative, preparation method therefor, and pharmaceutical application thereof CYP19A1, HSD17B11, CYP51A1 SMN1; SMN2 4872/4885L3MBTL1 4740/4885HTT 4712/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.