SCHEMBL6697960

SCHEMBL6697960

COc1ccc2sc(SNC3CCCCC3)nc2c1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.63
HPGD P15428 2/20 0.63
TDP1 Q9NUW8 1/20 0.63
MAOA P21397 1/20 0.50
MAOB P27338 1/20 0.50
NPC1 O15118 5/20 0.48
RAB9A P51151 5/20 0.48
MAPT P10636 3/20 0.48
PPARA Q07869 4/20 0.48
SMN1; SMN2 Q16637 4/20 0.46
DYRK1A Q13627 3/20 0.46
PDK1 Q15118 1/20 0.46
HPGDS O60760 2/20 0.42
TP53 P04637 2/20 0.42
POLB P06746 1/20 0.42
ALOX15 P16050 1/20 0.41
MAPK1 P28482 1/20 0.41
ITK Q08881 1/20 0.41
KDM4E B2RXH2 1/20 0.41
MEN1 O00255 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6694184 0.90 ALDH1A1 (0.63) ALDH1A1HPGDTDP1MAOAMAOB
SCHEMBL6690280 0.87 TDP1 (0.59) ALDH1A1HPGDTDP1NPC1RAB9A
SCHEMBL6690602 0.85 TDP1 (0.57) ALDH1A1HPGDTDP1MAOAMAOB
SCHEMBL6690578 0.78 PPARA (0.48) MAOAMAOBNPC1RAB9AMAPT
SCHEMBL6694865 0.78 MAPT (0.61) ALDH1A1HPGDTDP1NPC1RAB9A
SCHEMBL80270 0.78 ALDH1A1 (1.00) ALDH1A1HPGDTDP1MAOBNPC1
SCHEMBL29658287 0.78 ALDH1A1 (1.00) ALDH1A1HPGDTDP1MAOBNPC1
SCHEMBL10714830 0.77 ALDH1A1 (0.97) ALDH1A1HPGDTDP1MAOBNPC1
SCHEMBL11445594 0.76 ALDH1A1 (0.97) ALDH1A1HPGDTDP1MAOBNPC1
SCHEMBL6690928 0.76 ALDH1A1 (0.57) ALDH1A1HPGDTDP1MAOAMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0869016-B1 Pneumatic radial tires BRIDGESTONE CORP (JP) 2004-03-03 EP disclosed
EP-0945482-B1 Rubber composition for tire tread and pneumatic tire using same BRIDGESTONE CORP (JP) 2004-01-28 EP disclosed
EP-0890605-B1 Pneumatic tire BRIDGESTONE CORP (JP) 2003-04-23 EP disclosed
EP-1277795-A2 Pneumatic tire BRIDGESTONE CORPORATION (JP) 2003-01-22 EP disclosed
US-20020010283-A1 RUBBER COMPOSITION BRIDGESTONE CORPORATION (JP) 2002-01-24 US disclosed
US-6336486-B1 Pneumatic radical tire having cap base tread BRIDGESTONE CORPORATION (JP) 2002-01-08 US disclosed
US-6242522-B1 A DIENE BASED SYNTHETIC RUBBER OR NATURAL RUBBER BLEND CONTAINING BUTADIENE-STYRENE RUBBER, ALUMINUM HYDROXIDE POWDER, SILICA POWDER, CARBON BLACK; LOW FUEL CONSUMPTION AND WEAR RESISTANCE; IMPROVED GRIPPING IN WET AND COLD SITUATIONS BRIDGESTONE CORPORATION (JP) 2001-06-05 US disclosed
US-6186204-B1 EXCELLENT STABILITY AND CONTROLLABILITY ON WET ROADS OR A COMBINATION OF STABILITY AND CONTROLLABILITY ON WET ROADS AND EXCELLENT COMFORT OF RIDE EVEN WHEN A VEHICLE IS VIBRATING THROUGHOUT THE LIFE OF THE PNEUMATIC TIRE BRIDGESTONE CORPORATION (JP) 2001-02-13 US disclosed
EP-0948029-A2 High pressure discharge lamp NGK INSULATORS, LTD. (JP) 1999-10-06 EP disclosed
EP-0890605-A2 Pneumatic tire BRIDGESTONE CORPORATION (JP) 1999-01-13 EP disclosed
EP-0869016-A2 Pneumatic radial tires Bridgestone Corporation (JP) 1998-10-07 EP disclosed
EP-0854168-A1 Rubber composition Bridgestone Corporation (JP) 1998-07-22 EP disclosed