SCHEMBL6694865

SCHEMBL6694865

CCOc1ccc2nc(SNC3CCCCC3)sc2c1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 7/20 0.61
NPC1 O15118 5/20 0.61
RAB9A P51151 5/20 0.61
PKM P14618 1/20 0.61
TDP1 Q9NUW8 3/20 0.59
ALDH1A1 P00352 3/20 0.59
HPGD P15428 2/20 0.59
KMT2A Q03164 3/20 0.52
SMN1; SMN2 Q16637 3/20 0.52
TP53 P04637 2/20 0.52
CYP3A4 P08684 2/20 0.52
MEN1 O00255 2/20 0.52
NFKB1 P19838 2/20 0.52
NFKB2 Q00653 2/20 0.52
RELA Q04206 2/20 0.52
CYP1A2 P05177 1/20 0.52
CYP2D6 P10635 1/20 0.52
CYP2C9 P11712 1/20 0.52
CYP2C19 P33261 1/20 0.52
LMNA P02545 3/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6690928 0.91 ALDH1A1 (0.57) MAPTNPC1RAB9APKMTDP1
SCHEMBL6690280 0.91 TDP1 (0.59) MAPTNPC1RAB9APKMTDP1
SCHEMBL6694184 0.87 ALDH1A1 (0.63) MAPTNPC1RAB9APKMTDP1
SCHEMBL6690602 0.82 TDP1 (0.57) MAPTNPC1RAB9APKMTDP1
SCHEMBL6691563 0.80 RAB9A (0.53) MAPTNPC1RAB9APKMTDP1
SCHEMBL6693725 0.79 MAPT (0.61) MAPTNPC1RAB9APKMTDP1
SCHEMBL6697960 0.78 ALDH1A1 (0.63) MAPTNPC1RAB9ATDP1ALDH1A1
SCHEMBL6689290 0.77 PDK1 (0.69) MAPTNPC1RAB9APKMTDP1
SCHEMBL6902202 0.77 MAPT (0.66) MAPTNPC1RAB9APKMTDP1
SCHEMBL6693785 0.77 PPARA (0.62) MAPTNPC1RAB9APKMTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0869016-B1 Pneumatic radial tires BRIDGESTONE CORP (JP) 2004-03-03 EP disclosed
EP-0945482-B1 Rubber composition for tire tread and pneumatic tire using same BRIDGESTONE CORP (JP) 2004-01-28 EP disclosed
EP-0890605-B1 Pneumatic tire BRIDGESTONE CORP (JP) 2003-04-23 EP disclosed
EP-1277795-A2 Pneumatic tire BRIDGESTONE CORPORATION (JP) 2003-01-22 EP disclosed
US-20020010283-A1 RUBBER COMPOSITION BRIDGESTONE CORPORATION (JP) 2002-01-24 US disclosed
US-6336486-B1 Pneumatic radical tire having cap base tread BRIDGESTONE CORPORATION (JP) 2002-01-08 US disclosed
US-6242522-B1 A DIENE BASED SYNTHETIC RUBBER OR NATURAL RUBBER BLEND CONTAINING BUTADIENE-STYRENE RUBBER, ALUMINUM HYDROXIDE POWDER, SILICA POWDER, CARBON BLACK; LOW FUEL CONSUMPTION AND WEAR RESISTANCE; IMPROVED GRIPPING IN WET AND COLD SITUATIONS BRIDGESTONE CORPORATION (JP) 2001-06-05 US disclosed
US-6186204-B1 EXCELLENT STABILITY AND CONTROLLABILITY ON WET ROADS OR A COMBINATION OF STABILITY AND CONTROLLABILITY ON WET ROADS AND EXCELLENT COMFORT OF RIDE EVEN WHEN A VEHICLE IS VIBRATING THROUGHOUT THE LIFE OF THE PNEUMATIC TIRE BRIDGESTONE CORPORATION (JP) 2001-02-13 US disclosed
EP-0948029-A2 High pressure discharge lamp NGK INSULATORS, LTD. (JP) 1999-10-06 EP disclosed
EP-0890605-A2 Pneumatic tire BRIDGESTONE CORPORATION (JP) 1999-01-13 EP disclosed
EP-0869016-A2 Pneumatic radial tires Bridgestone Corporation (JP) 1998-10-07 EP disclosed
EP-0854168-A1 Rubber composition Bridgestone Corporation (JP) 1998-07-22 EP disclosed