SCHEMBL6690928

SCHEMBL6690928

CCCCOc1ccc2nc(SNC3CCCCC3)sc2c1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.57
HPGD P15428 2/20 0.57
TDP1 Q9NUW8 2/20 0.57
MAPT P10636 5/20 0.52
NPC1 O15118 4/20 0.52
RAB9A P51151 4/20 0.52
PKM P14618 1/20 0.52
CSF1R P07333 4/20 0.47
MAOA P21397 1/20 0.46
MAOB P27338 1/20 0.46
LMNA P02545 3/20 0.45
HTT P42858 2/20 0.43
HSP90AA1 P07900 1/20 0.43
TSHR P16473 1/20 0.43
PPARA Q07869 1/20 0.43
L3MBTL1 Q9Y468 2/20 0.43
MAPK1 P28482 1/20 0.43
MEN1 O00255 1/20 0.42
TP53 P04637 1/20 0.42
CYP1A2 P05177 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6690602 0.91 TDP1 (0.57) ALDH1A1HPGDTDP1MAPTNPC1
SCHEMBL6694865 0.91 MAPT (0.61) ALDH1A1HPGDTDP1MAPTNPC1
SCHEMBL6694184 0.85 ALDH1A1 (0.63) ALDH1A1HPGDTDP1MAPTNPC1
SCHEMBL6690280 0.82 TDP1 (0.59) ALDH1A1HPGDTDP1MAPTNPC1
SCHEMBL6697861 0.80 RAB9A (0.46) ALDH1A1TDP1MAPTNPC1RAB9A
SCHEMBL6688601 0.80 PPARA (0.50) ALDH1A1TDP1MAPTNPC1RAB9A
SCHEMBL6691987 0.78 PDK1 (0.66) ALDH1A1HPGDTDP1MAPTNPC1
SCHEMBL6900878 0.78 PDK1 (0.54) ALDH1A1HPGDTDP1MAPTNPC1
SCHEMBL6691037 0.78 PPARA (0.51) ALDH1A1TDP1MAPTNPC1RAB9A
SCHEMBL6690259 0.77 ALDH1A1 (0.53) ALDH1A1HPGDTDP1MAPTHSP90AA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0869016-B1 Pneumatic radial tires BRIDGESTONE CORP (JP) 2004-03-03 EP disclosed
EP-0945482-B1 Rubber composition for tire tread and pneumatic tire using same BRIDGESTONE CORP (JP) 2004-01-28 EP disclosed
EP-0890605-B1 Pneumatic tire BRIDGESTONE CORP (JP) 2003-04-23 EP disclosed
EP-1277795-A2 Pneumatic tire BRIDGESTONE CORPORATION (JP) 2003-01-22 EP disclosed
US-20020010283-A1 RUBBER COMPOSITION BRIDGESTONE CORPORATION (JP) 2002-01-24 US disclosed
US-6336486-B1 Pneumatic radical tire having cap base tread BRIDGESTONE CORPORATION (JP) 2002-01-08 US disclosed
US-6242522-B1 A DIENE BASED SYNTHETIC RUBBER OR NATURAL RUBBER BLEND CONTAINING BUTADIENE-STYRENE RUBBER, ALUMINUM HYDROXIDE POWDER, SILICA POWDER, CARBON BLACK; LOW FUEL CONSUMPTION AND WEAR RESISTANCE; IMPROVED GRIPPING IN WET AND COLD SITUATIONS BRIDGESTONE CORPORATION (JP) 2001-06-05 US disclosed
US-6186204-B1 EXCELLENT STABILITY AND CONTROLLABILITY ON WET ROADS OR A COMBINATION OF STABILITY AND CONTROLLABILITY ON WET ROADS AND EXCELLENT COMFORT OF RIDE EVEN WHEN A VEHICLE IS VIBRATING THROUGHOUT THE LIFE OF THE PNEUMATIC TIRE BRIDGESTONE CORPORATION (JP) 2001-02-13 US disclosed
EP-0948029-A2 High pressure discharge lamp NGK INSULATORS, LTD. (JP) 1999-10-06 EP disclosed
EP-0890605-A2 Pneumatic tire BRIDGESTONE CORPORATION (JP) 1999-01-13 EP disclosed
EP-0869016-A2 Pneumatic radial tires Bridgestone Corporation (JP) 1998-10-07 EP disclosed
EP-0854168-A1 Rubber composition Bridgestone Corporation (JP) 1998-07-22 EP disclosed