Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.32 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3807916 | 0.99 | ALDH1A1 (0.37) | ALDH1A1SMN1; SMN2MDM2MEN1KMT2A | |
| SCHEMBL6692752 | 0.86 | GABBR2 (0.42) | ALDH1A1SMN1; SMN2MDM2MEN1KMT2A | |
| SCHEMBL6698206 | 0.85 | MDM2 (0.36) | ALDH1A1SMN1; SMN2MDM2MEN1KMT2A | |
| SCHEMBL3815691 | 0.84 | GABBR2 (0.43) | ALDH1A1SMN1; SMN2MDM2MEN1KMT2A | |
| SCHEMBL3809788 | 0.81 | ALDH1A1 (0.36) | ALDH1A1SMN1; SMN2MDM2MEN1KMT2A | |
| SCHEMBL2484985 | 0.81 | MAPT (0.41) | ALDH1A1SMN1; SMN2MEN1KMT2AMAPT | |
| Hydrochloric Acid SCHEMBL2485648 | 0.80 | MAPT (0.40) | ALDH1A1SMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL3809899 | 0.80 | ALDH1A1 (0.37) | ALDH1A1SMN1; SMN2MDM2MEN1KMT2A | |
| SCHEMBL3809657 | 0.79 | ALDH1A1 (0.34) | ALDH1A1SMN1; SMN2MDM2MEN1KMT2A | |
| SCHEMBL3807741 | 0.76 | ALDH1A1 (0.37) | ALDH1A1SMN1; SMN2MDM2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6797712-B2 | Substituted amino-furan-2-yl-acetic acid and amino-thien-2-yl-acetic acid derivatives and their use in the treatment of migraine and pain | GRUENENTHAL GMBH (DE) | 2004-09-28 | — | — | US | disclosed |
| US-20040030156-A1 | Substituted amino-furan-2-yl-acetic acid and amino-thien-2-yl-acetic acid derivatives and their use in the treatment of migraine and pain | GRUENENTHAL GMBH (DE) | 2004-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040030156-A1 | Substituted amino-furan-2-yl-acetic acid and amino-thien-2-yl-acetic acid derivatives and their use in the treatment of migraine and pain | AADAT, TRPA1, CACNA1I | ALDH1A1 601/4885SMN1; SMN2 992/4885MDM2 4277/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.